(racemic)-4,4-dimethyl-N-(4-(1-piperazinyl)phenyl)spiro[cyclohex-2-ene-1,9'-pyrido[4',3':3,4]cyclopenta[1,2-d]pyrimidin]-2'-amine | 1190961-76-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (racemic)-4,4-dimethyl-N-(4-(1-piperazinyl)phenyl)spiro[cyclohex-2-ene-1,9'-pyrido[4',3':3,4]cyclopenta[1,2-d]pyrimidin]-2'-amine
• 英文别名: 6',6'-dimethyl-N-(4-piperazin-1-ylphenyl)spiro[4,6,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaene-8,3'-cyclohexene]-5-amine
• CAS: 1190961-76-2
• 化学式: C₂₇H₃₀N₆
• 分子量: 438.575
• InChiKey: BCMALGYLQMMZKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  66
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS<br/>[FR] PYRIDINES/PYRIMIDINES AMINO SPIROCYCLIQUES ET DISUBSTITUÉES PAR GEM EN TANT QU'INHIBITEURS DE CYCLE CELLULAIRE
  申请人：AMGEN INC

  公开号：WO2009126584A1

  公开（公告）日：2009-10-15

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.

  提供了一些化合物、药物组合物和方法，这些化合物、药物组合物和方法可用于治疗CDK4介导的疾病，如癌症。所述化合物是 gem-二取代或螺环的吡啶、嘧啶和三嗪衍生物。
• Lactone compounds which can be used as antioxidant agents in pharmaceutical, cosmetic or food compositions and their method of preparation
  申请人：Mioskoski Charles

  公开号：US20110098351A1

  公开（公告）日：2011-04-28

  The subject of the present invention is specific lactone compounds which can be used as antioxidant agents in pharmaceutical or cosmetic compositions or in food products, the said compounds containing a naphthalene ring onto which two lactone units are grafte.

  本发明涉及特定的内酯化合物，可用作药用或化妆品组合物或食品产品中的抗氧化剂，所述化合物含有一个萘环，上面嫁接了两个内酯单元。
• PROCESS FOR THE PREPARATION OF PHENOL BY MEANS OF NEW CATALYTIC SYSTEMS
  申请人：Minisci Francesco

  公开号：US20110098509A1

  公开（公告）日：2011-04-28

  The invention relates to a process for the preparation of phenol which comprises the aerobic oxidation of cumene to hydroperoxide with high conversions and selectivities, in the presence of new catalytic systems, extremely mild conditions and the subsequent acid decomposition of the hydroperoxide to phenol and acetone.

  本发明涉及一种制备苯酚的工艺，包括在新的催化系统存在下，在极其温和的条件下，通过对双异丙苯进行氧化反应，高效地转化成过氧化氢，并随后通过酸分解过氧化氢生成苯酚和丙酮。
• Gem-Disubstituted and Spirocyclic Amino Pyridines/Pyrimidines as Cell Cycle Inhibitors
  申请人：Connors Richard V.

  公开号：US20110097305A1

  公开（公告）日：2011-04-28

  Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-me-dialed disorders, such as cancer. The subject compounds arc gem-disubstituted or spimcyclic pyridine, pyrimidine and triazine derivatives.

  本文提供了化合物、药物组合物和方法，用于治疗CDK4介导的疾病，如癌症。所述化合物为gem-二取代或螺环式吡啶、嘧啶和三嗪衍生物。
• SELECTIVE OXIDATION OF ALKYLBENZENES
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：EP1966114B1

  公开（公告）日：2010-11-17