2-amino-6-methoxy-9-(2'-C-methyl-β-D-ribofuranosyl)purine-5'-O-[(benzoxy-L-alaninyl)(2,2-dimethylpropoxy-L-alaninyl)]phosphate | 1350765-80-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 2-amino-6-methoxy-9-(2'-C-methyl-β-D-ribofuranosyl)purine-5'-O-[(benzoxy-L-alaninyl)(2,2-dimethylpropoxy-L-alaninyl)]phosphate
• 英文别名: (2S)-benzyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)((S)-1-(neopentyloxy)-1-oxopropan-2-ylamino)phosphorylamino)propanoate；benzyl (2S)-2-[[[(2R,3R,4R,5R)-5-(2-amino-6-methoxypurin-9-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-[[(2S)-1-(2,2-dimethylpropoxy)-1-oxopropan-2-yl]amino]phosphoryl]amino]propanoate
• CAS: 1350765-80-8
• 化学式: C₃₀H₄₄N₇O₁₀P
• 分子量: 693.694
• InChiKey: JQAFAGRSICSQKO-MZSNYCRNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  48
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  232
• 氢给体数：
  5
• 氢受体数：
  16

文献信息

• [EN] PHOSPHORODIAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INJECTIONS<br/>[FR] DÉRIVÉS PHOSPHORODIAMIDATE DE COMPOSÉS NUCLÉOSIDIQUES À BASE DE GUANOSINE DESTINÉS À TRAITER DES INFECTIONS VIRALES
  申请人：INHIBITEX INC

  公开号：WO2012048013A2

  公开（公告）日：2012-04-12

  This invention is directed to novel compounds of formula (I) having the structure that are useful in the treatment of viral infections in mammals mediated, at least in part, by a virus in the Flaviviridae family of viruses. Methods of treating viral infections via administration of these compounds are also disclosed.