N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-propionamide | 908138-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-propionamide
• CAS: 908138-98-7
• 化学式: C₃₇H₃₇N₃O₉
• 分子量: 667.715
• InChiKey: RJTAINUQYDEBRT-VOTWKOMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.38
• 重原子数：
  49.0
• 可旋转键数：
  13.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  154.25
• 氢给体数：
  3.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-propionamide 、 alkaline earth salt of/the/ methylsulfuric acid 生成
  参考文献：
  名称：

  THE SYNTHESIS OF DIENE-CONTAINING NUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE IN THE LABELING OF OLIGONUCLEOTIDES

  摘要：

  A variety of furan-modified nucleoside phosphoramidite monomers has been prepared and efficiently incorporated into oligonucleotides. These take part in Diels-Alder reactions with fluorescent maleimides to give fluorescent-labeled oligonucleotides. This represents a strategy for oligonucleotide labeling that is orthogonal to amine-based methods.

  DOI：

  10.1081/ncn-200060085
• 作为产物：
  描述：

  5'-O-[二(4-甲氧基苯基)苯基甲基]-5-溴-2'-脱氧尿苷 在 氨 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 生成 N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-furan-2-yl-propionamide
  参考文献：
  名称：

  THE SYNTHESIS OF DIENE-CONTAINING NUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE IN THE LABELING OF OLIGONUCLEOTIDES

  摘要：

  A variety of furan-modified nucleoside phosphoramidite monomers has been prepared and efficiently incorporated into oligonucleotides. These take part in Diels-Alder reactions with fluorescent maleimides to give fluorescent-labeled oligonucleotides. This represents a strategy for oligonucleotide labeling that is orthogonal to amine-based methods.

  DOI：

  10.1081/ncn-200060085