(4-methyl-1-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone | 1018990-64-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4-methyl-1-((tetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone
• 英文别名: [4-Methyl-1-(oxan-4-ylmethyl)piperidin-4-yl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
• CAS: 1018990-64-1
• 化学式: C₂₄H₃₄F₃N₃O₂
• 分子量: 453.548
• InChiKey: KDHHDEWOULFFLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  36
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• CARBOXAMIDE COMPOUNDS AND THEIR USE
  申请人：Lin Jian

  公开号：US20100210633A1

  公开（公告）日：2010-08-19

  Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

  本文介绍了化学因子受体拮抗剂，特别是公式(I)化合物，它们作为化学因子CCR2受体的拮抗剂，包括制药组合物及其用途，用于治疗或预防与单核细胞聚集、淋巴细胞聚集或白细胞聚集相关的疾病。
• [EN] CARBOXAMIDE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS DE CARBOXAMIDE ET LEUR UTILISATION
  申请人：EPIX DELAWARE INC

  公开号：WO2008045564A2

  公开（公告）日：2008-04-17

  (EN) Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.(FR) L'invention concerne des antagonistes du récepteur de chimiokine, en particulier, des composés de formule (I) qui agissent comme antagonistes du récepteur CCR2 de la chimiokine, incluant des compositions pharmaceutiques et des utilisations de celles-ci pour traiter ou prévenir des maladies associées à une accumulation de monocytes, une accumulation de lymphocytes ou une accumulation de leucocytes.