1-(3-Thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazole-5-carbonyl)-piperidine-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(3-Thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazole-5-carbonyl)-piperidine-4-carboxylic acid
• 英文别名: 1-(3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazole-5-carbonyl)piperidine-4-carboxylic acid
• 化学式: C₂₁H₁₉N₃O₃S
• 分子量: 393.466
• InChiKey: WZBKYTHQUNBRJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(3-Thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazole-5-carbonyl)-piperidine-4-carboxylic acid 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 [1-[(3-Thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazol-5-yl)methyl]piperidin-4-yl]methanol
  参考文献：
  名称：

  Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

  摘要：

  We report the synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted kinase inhibitors. Initial efforts focused on the development of selective KDR inhibitors, while later strategies involved the improvement of potency toward multiple kinase targets. Thus, several compounds were identified as potent KDR, Flt1, Flt3, and c-Kit inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.031
• 作为产物：
  描述：

  3-(2-羧基苯基)丙酸 在 三氯化铝 、 sodium chloride 作用下， 反应 2.0h， 生成 1-(3-Thiophen-3-yl-2,4-dihydro-indeno[1,2-c]pyrazole-5-carbonyl)-piperidine-4-carboxylic acid
  参考文献：
  名称：

  Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors

  摘要：

  We report the synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted kinase inhibitors. Initial efforts focused on the development of selective KDR inhibitors, while later strategies involved the improvement of potency toward multiple kinase targets. Thus, several compounds were identified as potent KDR, Flt1, Flt3, and c-Kit inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.031

文献信息

• Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors
  作者：Irini Akritopoulou-Zanze、Daniel H. Albert、Peter F. Bousquet、George A. Cunha、Christopher M. Harris、Maria Moskey、Jurgen Dinges、Kent D. Stewart、Thomas J. Sowin

  DOI：10.1016/j.bmcl.2007.03.031

  日期：2007.6

  We report the synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted kinase inhibitors. Initial efforts focused on the development of selective KDR inhibitors, while later strategies involved the improvement of potency toward multiple kinase targets. Thus, several compounds were identified as potent KDR, Flt1, Flt3, and c-Kit inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.