[6-(4-methyl-piperazin-1-yl)-pyridin-2-yl]-(3-m-tolyl-azetidin-1-yl)-methanone | 1175691-59-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [6-(4-methyl-piperazin-1-yl)-pyridin-2-yl]-(3-m-tolyl-azetidin-1-yl)-methanone
• 英文别名: [3-(3-Methylphenyl)azetidin-1-yl]-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]methanone
• CAS: 1175691-59-4
• 化学式: C₂₁H₂₆N₄O
• 分子量: 350.464
• InChiKey: KXTMOEFSESNBMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  39.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders
  申请人：Collantes Elizabeth Martha

  公开号：US20090197859A1

  公开（公告）日：2009-08-06

  The present invention relates to novel pyridinyl derivatives of Formula wherein Y, Z, L, R 1 through R 11 , n, m, p, q, t are as defined herein, that are 5-HT receptor ligands, particularly the 5-HT6 subtype, and as such are useful for treating diseases wherein modulation of 5-HT activity is desired. The present invention relates to novel pyridinyl derivatives including their pharmaceutically acceptable salts. The invention also relates to processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions containing and the uses of such compounds in treating diseases of the central nervous system such as schizophrenia.

  本发明涉及一种新颖的吡啶基衍生物，其化学式如下所示：其中Y、Z、L、R1至R11、n、m、p、q、t的定义如本文所述，它们是5-HT受体配体，特别是5-HT6亚型，因此可用于治疗需要调节5-HT活性的疾病。本发明涉及包括其药用盐在内的新型吡啶基衍生物。该发明还涉及用于制备、制备中间体、含有这些化合物的药物组合物以及在治疗中枢神经系统疾病如精神分裂症中使用这些化合物的过程。
• N-thiazol-2-yl-benzamide derivatives
  申请人：Sams Graven Anette

  公开号：US20060154974A1

  公开（公告）日：2006-07-13

  The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are A 2A -receptor ligands, such as antagonists, agonists, reverse agonists or partial agonists, and are useful in the treatment of neurological and psychiatric disorders where an A 2A -receptor is implicated.

  本发明涉及公式I的化合物，其中变量如权利要求所定义。该化合物是A2A受体配体，如拮抗剂，激动剂，反向激动剂或部分激动剂，并且在治疗涉及A2A受体的神经和精神障碍方面有用。
• N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES
  申请人：Sams Anette Graven

  公开号：US20090247593A1

  公开（公告）日：2009-10-01

  The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are A 2A -receptor ligands, such as antagonists, agonists, reverse agonists or partial agonists, and are useful in the treatment of neurological and psychiatric disorders where an A 2A -receptor is implicated.

  本发明涉及式I的化合物，其中变量如权利要求所定义。这些化合物是A2A受体配体，例如拮抗剂、激动剂、反向激动剂或部分激动剂，并且在治疗神经系统和精神障碍中，其中涉及到A2A受体时具有用处。