2-Propionyl-3-methylbenzofuran | 51699-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-Propionyl-3-methylbenzofuran
• 英文别名: 1-(3-methyl-benzofuran-2-yl)-propan-1-one；1-(3-Methyl-1-benzofuran-2-yl)propan-1-one
• CAS: 51699-27-5
• 化学式: C₁₂H₁₂O₂
• 分子量: 188.226
• InChiKey: IFTGEYPXVFVJNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Modulators of Cellular Adhesion
  申请人：Shen Wang

  公开号：US20110124625A1

  公开（公告）日：2011-05-26

  The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R 1 -R 4 , n, p, A, B, D, E, L and AR 1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).

  本发明提供了具有式(I)的化合物及其药学上可接受的衍生物，其中R1-R4、n、p、A、B、D、E、L和AR1如本文中一般和各类和子类中所述，并且还提供了其药物组成物以及使用它们治疗由CD11/CD18细胞粘附分子（例如LFA-1）介导的疾病的方法。
• Verwendung substituierter 2-Acetylbenzofurane als Riechstoffe
  申请人：HAARMANN & REIMER GMBH

  公开号：EP0826764A2

  公开（公告）日：1998-03-04

  Bestimmte 2-Carbonylbenzofurane und 2-Carbonyl-2,3-dihydrobenzofurane sind ausgezeichnete Riechstoffe.

  某些 2-羰基苯并呋喃和 2-羰基-2,3-二氢苯并呋喃是极好的气味剂。
• Riechstoffkompositionen enthaltend substituierte 2-Acetylbenzofurane
  申请人：HAARMANN & REIMER GMBH

  公开号：EP0826764B1

  公开（公告）日：2003-02-26
• MODULATORS OF CELLULAR ADHESION
  申请人：Shen Wang

  公开号：US20080182839A1

  公开（公告）日：2008-07-31

  The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof; wherein R 1 -R 4 , n, p, A, B, D, E, L and AR 1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof; and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
• Modulators of cellular adhesion
  申请人：Shen Wang

  公开号：US20080176896A1

  公开（公告）日：2008-07-24

  The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R 1 -R 4 , n, p, A, B, D, E, L and AR 1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).