2-oxo-2-(4-phenylpiperazin-1-yl)ethyl 5-(tetradecyloxy)furan-2-carboxylate | 1261491-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-oxo-2-(4-phenylpiperazin-1-yl)ethyl 5-(tetradecyloxy)furan-2-carboxylate
• 英文别名: [2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl] 5-tetradecoxyfuran-2-carboxylate
• CAS: 1261491-88-6
• 化学式: C₃₁H₄₆N₂O₅
• 分子量: 526.717
• InChiKey: YBVNEVCDUSKTQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  38
• 可旋转键数：
  19
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  72.2
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] TOFA ANALOGS USEFUL IN TREATING DERMATOLOGICAL DISORDERS OR CONDITIONS<br/>[FR] ANALOGUES DE TOFA UTILE DANS LE TRAITEMENT DE TROUBLES OU ÉTATS DERMATOLOGIQUES
  申请人：VALOCOR THERAPEUTICS INC

  公开号：WO2011005660A1

  公开（公告）日：2011-01-13

  This invention is directed to analogs of 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA) and their use in the treatment of dermatological disorders or conditions characterized by sebaceous gland hyperactivity, such as acne and oily skin, and other dermatological disorders and conditions. This invention is also directed to pharmaceutical compositions comprising analogs of TOFA and a pharmaceutically acceptable excipient for dermatological or oral administration. Formula (I)

  本发明涉及5-(十四氧基)-2-呋喃羧酸（TOFA）的类似物及其在治疗皮肤病或由皮脂腺过度活跃引起的状况，如痤疮和油性皮肤，以及其他皮肤病和状况中的应用。本发明还涉及包含TOFA类似物和药用可接受的载体的制药组合物，用于皮肤或口服治疗。公式（I）
• TOFA ANALOGS USEFUL IN TREATING DERMATOLOGICAL DISORDERS OR CONDITIONS
  申请人：Daynard Timothy Scott

  公开号：US20120208807A1

  公开（公告）日：2012-08-16

  This invention is directed to analogs of 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA) and their use in the treatment of dermatological disorders or conditions characterized by sebaceous gland hyperactivity, such as acne and oily skin, and other dermatological disorders and conditions. This invention is also directed to pharmaceutical compositions comprising analogs of TOFA and a pharmaceutically acceptable excipient for dermatological or oral administration. Formula (I)

  本发明涉及5-(十四氧基)-2-呋喃羧酸（TOFA）的类似物及其在治疗皮肤疾病或皮肤状况中的应用，包括皮肤痤疮和油性皮肤以及其他皮肤疾病和状况。本发明还涉及制备TOFA类似物的药物组合物，其中含有药用可接受的辅料，用于皮肤或口服给药。公式（I）
• Tofa analogs useful in treating dermatological disorders or conditions
  申请人：Dermira (Canada), Inc.

  公开号：EP2641906B1

  公开（公告）日：2015-04-22
• US8884034B2
  申请人：——

  公开号：US8884034B2

  公开（公告）日：2014-11-11
• US9434718B2
  申请人：——

  公开号：US9434718B2

  公开（公告）日：2016-09-06