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2-(6-hydroxy-benzofuran-3-yl)-propionic acid methyl ester | 726174-53-4

中文名称
——
中文别名
——
英文名称
2-(6-hydroxy-benzofuran-3-yl)-propionic acid methyl ester
英文别名
Methyl 2-(6-hydroxy-1-benzofuran-3-yl)propanoate
2-(6-hydroxy-benzofuran-3-yl)-propionic acid methyl ester化学式
CAS
726174-53-4
化学式
C12H12O4
mdl
——
分子量
220.225
InChiKey
HIZAWDWPLNYOKB-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.3
  • 重原子数:
    16
  • 可旋转键数:
    3
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.25
  • 拓扑面积:
    59.7
  • 氢给体数:
    1
  • 氢受体数:
    4

文献信息

  • [EN] FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS<br/>[FR] DERIVES HETEROCYCLIQUES FUSIONNES UTILISES EN TANT QUE MODULATEURS PPAR
    申请人:LILLY CO ELI
    公开号:WO2004063155A1
    公开(公告)日:2004-07-29
    The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S. S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.
    本发明涉及由以下结构式I表示的化合物:其中(a)X选自单键、O、S、S(O)2和N组成的群;(b)U是脂肪链连接物;(c)Y选自C、O、S、NH和单键组成的群;(d)E是C(R3)(R4)A或A,其中(i)A选自羧基、四唑基、C1-C6烷基腈、羧酰胺、磺酰胺和酰基磺酰胺组成的群;(e)B选自S、O、C和N组成的群;(f)Z选自N和C组成的群;但当B为C时,则Z为N。
  • Fused heterocyclic derivates as ppar modulators
    申请人:Conner Eugene Scott
    公开号:US20060217374A1
    公开(公告)日:2006-09-28
    The present invention is directed to a method of treatment by modulating a peroxisome proliferator activated receptor by employing a compound of Structural Formula (I). The variables in I are defined herein. Also included are compounds, methods of making compounds, and pharmaceutical compositions. The compounds of the present invention are believed to be effective in treating and preventing Syndrome X, Type H diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, atherosclerosis, and other disorders related to Syndrome X and cardiovascular diseases.
    本发明涉及一种通过利用结构式(I)的化合物来调节过氧化物酶体增殖物激活受体进行治疗的方法。I中的变量在此定义。还包括化合物、制备化合物的方法和制药组合物。本发明的化合物被认为在治疗和预防综合征X、H型糖尿病、高血糖、高脂血症、肥胖症、凝血障碍、高血压、动脉粥样硬化和其他与综合征X和心血管疾病相关的疾病方面具有疗效。
  • Fused heterocyclic derivatives as ppar modulators
    申请人:Conner Eugene Scott
    公开号:US20060205744A1
    公开(公告)日:2006-09-14
    The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S, S(O) 2 and N; (b) U is an aliphatic linker, (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4) A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C 1 -C 6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.
    本发明涉及由以下结构式表示的化合物,即式 I: 其中 (a) X 选自单键、O、S、S(O) 2 和 N 所组成的组;(b) U 是脂肪族连接体,(c) Y 选自 C、O、S、NH 和单键组成的组;(d) E 是 C(R3) (R4) A 或 A,其中(i) A 选自羧基、四唑、C 1 -C 6 烷基腈、羧酰胺、磺酰胺和酰基磺酰胺组成的组; (e) B 选自 S、O、C 和 N 组成的组; (f) Z 选自 N 和 C 组成的组;但当 B 为 C 时,Z 为 N。
  • FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS
    申请人:ELI LILLY AND COMPANY
    公开号:EP1581521A1
    公开(公告)日:2005-10-05
  • Bicyclic derivatives as ppar modulators
    申请人:Conner Eugene Scott
    公开号:US20070106081A1
    公开(公告)日:2007-05-10
    The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R2 is selected from the group consisting of C 0 -C 8 alkyl and C 1-4 -heteroalkyl; (b) X is selected from the group consisting of a single bond, O, S, S(O) 2 and N; (c) U is an aliphatic linker wherein one carbon atom of the aliphatic linker is optionally replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with from one to four substituents each independently selected from R30; (d) Y is selected from the group consisting of C, O, S, NH and a single bond; and (e) E is C(R3)(R4)A or A.
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