| 1187890-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• CAS: 1187890-31-8
• 化学式: C₃₀H₃₆N₂O₂
• 分子量: 456.628
• InChiKey: INBVXQHXJFTWRJ-IZLXSDGUSA-N

反应信息

• 作为反应物：
  描述：

  在 氢气 、 palladium(II) hydroxide 作用下， 以 甲醇 为溶剂， 以95%的产率得到tert-butyl (2S,3R)-3-amino-2-phenyl-1-piperidinecarboxylate
  参考文献：
  名称：

  Asymmetric synthesis of (2S,3R)-(−)-epi-CP-99,994 using sulfinimine-derived anti-2,3-diamino esters

  摘要：

  A differentially protected C-3 N-sulfinyl, C-2 N,N-(diphenylmethylene) 2,3-diamino ester was employed in the synthesis of the amino piperidine (2S,3R)-(-)-epi-CP-99,994. Key steps in the synthesis included the chemoselective hydrolysis of the C-2 N,N-(diphenylmethylene) group and its reprotection as a dibenzylamino group. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.125
• 作为产物：
  描述：

  tert-butyl (2S,3R)-3-(dibenzylamino)-2-phenyl-3,6-dihydro-2H-pyridine-1-carboxylate 在 platinum on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 以96%的产率得到
  参考文献：
  名称：

  Asymmetric synthesis of (2S,3R)-(−)-epi-CP-99,994 using sulfinimine-derived anti-2,3-diamino esters

  摘要：

  A differentially protected C-3 N-sulfinyl, C-2 N,N-(diphenylmethylene) 2,3-diamino ester was employed in the synthesis of the amino piperidine (2S,3R)-(-)-epi-CP-99,994. Key steps in the synthesis included the chemoselective hydrolysis of the C-2 N,N-(diphenylmethylene) group and its reprotection as a dibenzylamino group. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.125