2-{[3-(1-amino-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)-1, 1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]oxy}acetamide | 691362-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 2-{[3-(1-amino-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)-1, 1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]oxy}acetamide
• 英文别名: 2-[[3-(1-amino-4-hydroxy-2-oxoquinolin-3-yl)-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazin-7-yl]oxy]acetamide；2-[[3-(1-amino-4-hydroxy-2-oxoquinolin-3-yl)-1,1-dioxo-4H-1λ6,2,4-benzothiadiazin-7-yl]oxy]acetamide
• CAS: 691362-55-7
• 化学式: C₁₈H₁₅N₅O₆S
• 分子量: 429.413
• InChiKey: VRPJLWLJXPTVCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  186
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Anti-infective agents
  申请人：——

  公开号：US20040162285A1

  公开（公告）日：2004-08-19

  Compounds having the formula 1 are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

  具有公式1的化合物是丙型肝炎病毒（HCV）聚合酶抑制剂。还公开了一种用于抑制丙型肝炎病毒（HCV）聚合酶的组成和方法，用于制造这些化合物的过程，以及在这些过程中使用的合成中间体。
• ANTI-INFECTIVE AGENTS
  申请人：Abbott Laboratories

  公开号：EP1560827A1

  公开（公告）日：2005-08-10
• US7902203B2
  申请人：——

  公开号：US7902203B2

  公开（公告）日：2011-03-08
• [EN] ANTI-INFECTIVE AGENTS<br/>[FR] AGENTS ANTI-INFECTIEUX
  申请人：ABBOTT LAB

  公开号：WO2004041818A1

  公开（公告）日：2004-05-21

  The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.