C-[3-(2,4-dichlorophenyl)-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]methylamine | 1223062-40-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: C-[3-(2,4-dichlorophenyl)-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]methylamine
• CAS: 1223062-40-5
• 化学式: C₁₇H₁₂Cl₂F₃N₃
• 分子量: 386.204
• InChiKey: FZHGABLPZORIMD-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 sodium cyanoborohydride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 C-[3-(2,4-dichlorophenyl)-1-(4-trifluoromethylphenyl)-1H-pyrazol-4-yl]methylamine
  参考文献：
  名称：

  (1,3-Diphenyl-1H-Pyrazol-4-yl)-Methylamine Analogues as Inhibitors of Dipeptidyl Peptidases

  摘要：

  AbstractA number of pyrazole compounds reported in literatures elicit anti‐hyperglycemic effects. By modifying the side chain of the heterocyclic skeleton, a new chemical class of DPP‐IV inhibitors structurally derived from the (pyrazol‐4‐yl)‐methylamine scaffold have been discovered and evaluated the biological activities of these inhibitors against DPP‐IV, DPP8, DPP‐II and FAP. The SAR studies showed the (1,3‐diphenyl‐1H‐pyrazol‐4‐yl)‐methylamines with 2,4‐dichloro substituents at the 3‐phenyl ring selectively preferred as DPP‐IV inhibitors, whereas with difluoro substituents at the 3‐phenyl ring selectively preferred as DPP8 inhibitors. The binding mode of representative compound 15h at the active site of DPP‐IV was predicted by computer model. In additional, 15h exhibited the ability to significantly decrease the glucose excursion in mice.

  DOI：

  10.1002/jccs.200900152