| 1332723-18-8

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机过渡后金属化合物
• CAS: 1332723-18-8
• 化学式: C₇H₁₄IS*I
• 分子量: 384.063
• InChiKey: QRJAPVRTOXDLPM-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.77
• 重原子数：
  10.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  4-甲基吡啶 、 在 乙酸酐 、 N,N-二异丙基乙胺 作用下， 生成
  参考文献：
  名称：

  Synthesis and fluorescence characteristics of novel asymmetric cyanine dyes for DNA detection

  摘要：

  Sixteen new asymmetric monomethine cyanine dyes have been synthesized and their spectral characteristics and interaction with double stranded DNA have been investigated. The dyes absorb in the region 453-519 nm and have molar absorptivities in the range 37.900-93.100IM(-1) cm(-1). The dyes do not have intrinsic fluorescence, but in the presence of dsDNA they exhibited a significant enhancement in fluorescence. The most pronounced increase was found for D9, D10, D12 and D16 allowing the recommendation of these dyes as the most sensitive DNA markers. Thermodynamic analysis of cyanine-DNA complexation was carried out using the McGhee & von Hippel non-cooperative excluded site model, and binding parameters have been derived. A hypothesis describing the DNA-dye binding mode has been proposed. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotochem.2010.10.002
• 作为产物：
  描述：

  四氢噻吩 、 1,3-二碘丙烷 以 丙酮 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and study of nucleic acids interactions of novel monomethine cyanine dyes

  摘要：

  Six asymmetric monomethine cyanine dyes have been synthesized and their spectral characteristics and interaction with double stranded (ds)DNA have been investigated for their prospective use as fluorescent markers in molecular biology. Therefore, the non-covalent binding of the compounds with dsDNA was explored. Apart from the fluorescence spectroscopy, the study includes UV/Vis spectrophotometry and circular dichroism spectroscopy, as well as the thermal melting experiments. Although the compounds show relatively low binding affinity toward dsDNA and do not have intrinsic fluorescence, in the presence of dsDNA they exhibited considerable enhancement in fluorescence intensity. Therefore the studied dyes show interesting platform for future modifications directed toward more sequence selective derivatives. The compound with the highest affinity toward dsDNA showed interesting anti-proliferative potential and specificity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2011.08.019