4-[4-(Cyclopentylmethyl)piperazin-1-yl]benzohydrazide | 823794-60-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[4-(Cyclopentylmethyl)piperazin-1-yl]benzohydrazide
• CAS: 823794-60-1
• 化学式: C₁₇H₂₆N₄O
• 分子量: 302.4
• InChiKey: LEQQFIAQAYVNNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  61.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• New compound
  申请人：Mizuno Hiroaki

  公开号：US20050014685A1

  公开（公告）日：2005-01-20

  This invention relates to new lipopeptide compound represented by the following general formula (I): Wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.

  本发明涉及一种由以下通式（I）表示的新脂肽化合物，其中R1、R2、R3、R4、R5和R6如描述中所定义，或其盐，具有抗微生物活性（特别是抗真菌活性）、β-1,3-葡聚糖合酶抑制活性，以及其制备方法、包括该化合物的制药组合物，以及用于预防和/或治疗包括Pneumocystis carinii感染（例如Pneumocystis carinii肺炎）在人类或动物中的传染病的方法。
• TAILORING THE GRAFTING DENSITY OF ORGANIC MODIFIERS AT SOLID/LIQUID INTERFACES
  申请人：——

  公开号：US20020106449A1

  公开（公告）日：2002-08-08

  A method of depositing a functional group on a surface portion of an elastic substrate comprises the steps of: (a) stretching an elastic substrate having an initial surface portion to form an enlarged surface portion from the initial surface portion; then (b) conjugating a functional group on the enlarged surface portion; and then (c) releasing the substrate to form a reduced surface portion from the enlarged surface portion, with the reduced surface portion having an area less than the enlarged surface portion, and with the reduced surface portion having the functional group deposited therein at a greater density than the enlarged surface portion.

  一种在弹性基板的表面部分沉积官能团的方法包括以下步骤 (a) 拉伸具有初始表面部分的弹性基底，以从初始表面部分形成扩大的表面部分；然后 (b) 在扩大的表面部分上共轭一个官能团；然后 (c) 释放衬底，从增大的表面部分形成缩小的表面部分，缩小的表面部分的面积小于增大的表面部分，缩小的表面部分的功能基团沉积密度大于增大的表面部分。
• US6423372B1
  申请人：——

  公开号：US6423372B1

  公开（公告）日：2002-07-23
• [EN] ANTIFUNGAL CYCLIC LIPOPEPTIDES<br/>[FR] LIPOPEPTIDES CYCLIQUES ANTIFONGIQUES
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2005005463A1

  公开（公告）日：2005-01-20

  [EN] This invention relates to new lipopeptide compound represented by the general formula (I): Wherein R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on beta-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
  [FR] La présente invention concerne de nouveaux composés lipopeptidiques représentée par la formule générale (I) ou un sel de celui-ci. Dans cette formule R<1>, R<2>, R<3>, R<4>, R<5> et R<6> sont tels que définis dans les descriptions. Ce composé possède des activités antimicrobiennes (en particulier des activités antifongiques), une activité inhibitrice sur la syntaxe ss-1,3-glucane synthase. Cette invention concerne aussi un processus de préparation de ce composé, une composition pharmaceutique comprenant ce composé est une technique prophylactique et/ou un traitement thérapeutique et de maladies infectieuses comprenant des infections par Pneumocystis carinii (par exemple la pneumonie Pneumocystis carinii) touchant des êtres humains ou des animaux.