N'-(4-methylphenyl)-γ-ureidopropylsilatrane | 1583309-92-5

• 英文名称: N'-(4-methylphenyl)-γ-ureidopropylsilatrane
• CAS: 1583309-92-5
• 化学式: C₁₇H₂₇N₃O₄Si
• 分子量: 365.505
• InChiKey: MNFGNQFTKXWVQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  对甲苯异氰酸酯 、 1-(3-aminopropyl)silatrane 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 N'-(4-methylphenyl)-γ-ureidopropylsilatrane
  参考文献：
  名称：

  Synthesis, Antitumor Activity, and SAR of N-Substituted γ-Aminopropylsilatrane Derivatives

  摘要：

  -Aminopropylsilatrane has been reported to possess biological activity against tumor cancer cells with low cytotoxicity in many kinds of silatranes. So some N-substituted -aminopropylsilatrane derivatives were synthesized and assayed by a primary anticancer screening against HT-29, Hela, and MDAMB435 cells by the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. The structures of these derivatives were confirmed by H-1 NMR, electrospray ionization-mass spectrometry, and elemental analysis. The structure-activity relationship showed that the N-substituted derivatives exhibit better activity in which the -amino group of the silatrane is connected with stronger electron-withdrawing groups.

  DOI：

  10.1080/10426507.2013.829835