4-[(2S,5R)-2,5-Dimethylpiperazin-1-yl]-2-methylbenzonitrile | 648423-55-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-[(2S,5R)-2,5-Dimethylpiperazin-1-yl]-2-methylbenzonitrile
• CAS: 648423-55-6
• 化学式: C₁₄H₁₉N₃
• 分子量: 229.325
• InChiKey: CELGQORPONHNLN-NEPJUHHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl]-2-methylbenzonitrile 在 1-氯乙基氯甲酸酯 、 甲醇 作用下， 以 1,1-二氯乙烷 为溶剂， 生成 4-[(2S,5R)-2,5-Dimethylpiperazin-1-yl]-2-methylbenzonitrile
  参考文献：
  名称：

  N-PHENYL-(2R,5S)DIMETHYLPIPERAZINE DERIVATIVE

  摘要：

  公开号：

  EP1557411B1

文献信息

• N-phenyl-(2r,5s) dimethylpiperadine derivative
  申请人：Taniguchi Nobuaki

  公开号：US20050261303A1

  公开（公告）日：2005-11-24

  The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.

  本发明涉及一种新型的N-苯基-(2R,5S)二甲基哌嗪衍生物，其作为抗雄激素剂具有足够的前列腺减少效果，与传统化合物相比具有出色的口服活性。本申请的化合物可用于预防或治疗前列腺癌、良性前列腺增生等疾病。本发明还提供了一种用于制备本发明化合物的新型中间体。
• Cyanophenyl derivative
  申请人：YAMANOUCHI PHARMACEUTICAL CO., LTD.

  公开号：US20040010037A1

  公开（公告）日：2004-01-15

  This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti-androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.

  本申请涉及一种哌嗪取代的新型氰基苯衍生物，其中取代的氨基甲酰基或取代的磺酰基团结合在哌嗪环上的一个氮原子上，该团可能具有芳基，杂环或类似的基团，可具有取代基。本申请的化合物具有抗雄激素作用，可用于预防或治疗前列腺癌，良性前列腺增生等疾病。
• N-Phenyl-(2R,5S)Dimethylpiperazine Derivative
  申请人：Taniguchi Nobuaki

  公开号：US20080214543A1

  公开（公告）日：2008-09-04

  The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.

  本发明涉及一种新型N-苯基-(2R,5S)二甲基哌嗪衍生物，其作为抗雄激素剂具有足够的前列腺减少效果，与传统化合物相比具有出色的口服活性。本申请的化合物在预防或治疗前列腺癌、良性前列腺增生等方面具有用途。本发明还提供了一种新型中间体，用于制备本发明的化合物。
• N-phenyl-(2R,5S) dimethylpiperazine derivative
  申请人：Astellas Pharma Inc.

  公开号：US07297698B2

  公开（公告）日：2007-11-20

  The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.

  本发明涉及一种新型N-苯基-(2R,5S)二甲基哌嗪衍生物，可用作抗雄激素剂，与传统化合物相比具有足够的前列腺缩小效果，并且口服活性优异。本申请的化合物可用于预防或治疗前列腺癌、良性前列腺增生等疾病。本发明还提供了一种新型中间体，用于生产本发明的化合物。
• N-phenyl-(2R,5S)dimethylpiperazine derivative
  申请人：Astellas Pharma Inc.

  公开号：US07666873B2

  公开（公告）日：2010-02-23

  The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.

  本发明涉及一种新型N-苯基-(2R,5S)二甲基哌嗪衍生物，其作为抗雄激素药物具有足够的前列腺缩小效果，与传统化合物相比具有优异的口服活性。本申请的化合物可用于预防或治疗前列腺癌、良性前列腺增生等疾病。本发明还提供了一种新型中间体，可用于生产本发明的化合物。