Talorasib | 2648584-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Talorasib
• 英文别名: 2-[(2S)-4-[(7S)-7-(8-chloronaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile
• CAS: 2648584-48-7
• 化学式: C₃₂H₃₄ClFN₆O₃
• 分子量: 605.1
• InChiKey: DOUDKPJUSUTSCJ-LXWOLXCRSA-N

文献信息

• OXYGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD AND APPLICATION THEREOF
  申请人：Shanghai Yingli Pharmaceutical Co. Ltd.

  公开号：EP4015520A1

  公开（公告）日：2022-06-22

  Disclosed are an oxygen-containing heterocyclic compound, a preparation method therefor and the use thereof. The present disclosure provides an oxygen-containing heterocyclic compound represented by formula I, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or an isotopic compound thereof. It is expected that the oxygen-containing heterocyclic compound can treat and/or prevent various Ras-mediated diseases.

  本发明公开了一种含氧杂环化合物、其制备方法及其用途。本公开提供了一种由式 I 代表的含氧杂环化合物、其药学上可接受的盐、其立体异构体、其同分异构体或其同位素化合物。含氧杂环化合物有望治疗和/或预防各种 Ras 介导的疾病。
• [EN] OXYGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD AND APPLICATION THEREOF<br/>[FR] COMPOSÉ HÉTÉROCYCLIQUE CONTENANT DE L'OXYGÈNE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION<br/>[ZH] 一种含氧杂环化合物、其制备方法及应用
  申请人：SHANGHAI YINGLI PHARM CO LTD

  公开号：WO2021109737A1

  公开（公告）日：2021-06-10

  一种含氧杂环化合物、其制备方法及应用。一种如式I所示的含氧杂环化合物、其药学上可接受的盐、其立体异构体、其互变异构体或其同位素化合物，该含氧杂环化合物有望治疗和/或预防由Ras介导的多种疾病。
• [EN] SUBSTITUTED DIHYDROPYRANOPYRIMIDINE COMPOUNDS AS KRAS INHIBITORS<br/>[FR] COMPOSÉS DE DIHYDROPYRANOPYRIMIDINE SUBSTITUÉS EN TANT QU'INHIBITEURS DE KRAS
  申请人：[en]ACCUTAR BIOTECHNOLOGY, INC.

  公开号：WO2022081655A1

  公开（公告）日：2022-04-21

  The present disclosure relates to novel compounds that inhibit KRAS G12C, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.