6-(3-(1-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)piperidin-4-yl)propoxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | 1046814-06-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-(3-(1-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)piperidin-4-yl)propoxy)-2-(methylsulfonyl)-1,2,3,4-tetrahydroisoquinoline
• 英文别名: 6-[3-[1-[5-[(4-methylpiperazin-1-yl)methyl]pyridin-2-yl]piperidin-4-yl]propoxy]-2-methylsulfonyl-3,4-dihydro-1H-isoquinoline
• CAS: 1046814-06-5
• 化学式: C₂₉H₄₃N₅O₃S
• 分子量: 541.758
• InChiKey: KJDNSLSJSWYOQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  77.6
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
  申请人：Alper Phillip B.

  公开号：US20100022515A1

  公开（公告）日：2010-01-28

  The invention provides compounds, pharmaceutical compositions comprising compound of following formula (I), and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119 (G protein-coupled receptor 119) such as obesity, diabetes and hyperlipidemia.

  本发明提供了以下式子(I)的化合物、含有该化合物的制药组合物，以及使用这些化合物治疗或预防与GPR119(G蛋白偶联受体119)活性相关的疾病或症状的方法，例如肥胖症、糖尿病和高脂血症。
• Nano-and micro-cellular foamed thin-walled material, and processes and apparatuses for making the same
  申请人：——

  公开号：US20020168509A1

  公开（公告）日：2002-11-14

  Polymeric materials having a plurality of cells formed therein are described. The polymeric materials include a foamed layer comprising a plurality of uniform microcells, nanocells or combinations thereof in a closed cell network, a transition layer positioned adjacent to the foamed layer, and at least one unfoamed outer layer positioned adjacent to the transition layer. The foamed layer may be present in a volume ranging from about 80 to about 99 percent based on the volume of the polymeric material, the transition layer may present in a volume ranging from about 0 to about 10 percent based on the volume of the polymeric material, and the at least one outer layer may be present in a volume ranging from about 0.01 to about 10 percent based on the volume of the polymeric material. Methods of making such polymeric materials are also described, as are apparatus for providing foamed polymeric materials.

  本文描述了具有多个细胞的聚合材料。这种聚合物材料包括一个发泡层，该层由多个均匀的微孔、纳米孔或它们的组合组成一个封闭的细胞网络，一个与发泡层相邻的过渡层，以及至少一个与过渡层相邻的未发泡外层。发泡层的体积可占聚合物材料体积的 80%至 99%，过渡层的体积可占聚合物材料体积的 0%至 10%，至少一个外层的体积可占聚合物材料体积的 0.01%至 10%。此外，还介绍了制造这种聚合材料的方法，以及提供发泡聚合材料的设备。
• Methods for preparing polymers in carbon dioxide having reactive functionality
  申请人：DeSimone M. Joseph

  公开号：US20050215746A1

  公开（公告）日：2005-09-29

  A method of forming a polymer having reactive functionality comprises providing a reaction mixture comprising at least one monomer having at least one reactive functional group and carbon dioxide; and polymerizing the at least one monomer in the reaction mixture to form a polymer having reactive functionality associated with the at least one reactive functional group.

  一种形成具有活性官能团的聚合物的方法，包括提供一种反应混合物，该混合物包含至少一种具有至少一种活性官能团的单体和二氧化碳；以及聚合反应混合物中的至少一种单体，以形成具有与至少一种活性官能团相关的活性官能团的聚合物。
• ASYMMETRIC MEMBRANE
  申请人：North Carolina State University

  公开号：EP1372831B1

  公开（公告）日：2005-03-16
• Methods of CO2-assisted reactive extrusion
  申请人：——

  公开号：US20030171495A1

  公开（公告）日：2003-09-11

  Methods of carrying out a reactive extrusion processes are described that include combining at least one polymer, oligomer, or combination thereof, a carbon dioxide containing fluid, and at least one reactant in an extruder to form a mixture such that the carbon dioxide containing fluid comes into intimate contact with the at least one polymer, oligomer, or combination thereof and assists in a reaction between the at least one polymer, oligomer, or combination thereof and the at least one reactant, and wherein the at least one polymer, oligomer, or combination thereof is modified upon reaction with the at least one reactant.