1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;hydrochloride | 67915-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;hydrochloride
• CAS: 67915-60-0
• 化学式: C26H29Cl3N4O4
• 分子量: 567.9
• InChiKey: RXIVDPZYGDNGOZ-MHUAFMOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.63
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  69.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Skin care compositions containing imidazoles and retinoids
  申请人：JOHNSON & JOHNSON CONSUMER PRODUCTS, INC.

  公开号：EP0586106A1

  公开（公告）日：1994-03-09

  Skin care compositions comprising a water-in-oil emulsion base containing retinoids, excluding Vitamin A acid, and at least one imidazole in a free base form and possessing good physical and chemical stability. The compositions further comprise a stabilizing system selcted from: a) a chelating agent and at least one oil-soluble antioxidant, b) a chelating agent and at least one water-soluble antioxidant; and c) antioxidant present in each of the oil and water phases of said emulsion.

  护肤组合物，包含一种油包水型乳液基质，其中含有维甲酸（不包括维生素 A 酸）和至少一种游离基形式的咪唑，并具有良好的物理和化学稳定性。 这些组合物还包含一种稳定体系，该稳定体系可从以下物质中选取： a) 螯合剂和至少一种油溶性抗氧化剂、 b) 螯合剂和至少一种水溶性抗氧化剂；以及 c) 存在于所述乳液的油相和水相中的抗氧化剂。
• PRESSURE SENSITIVE ADHESIVE MATRIX DEVICE OR SYSTEM FOR THE TREATMENT OR PREVENTION OF ONYCHOMYCOSIS OR TINEA PEDIS
  申请人：Yang Kuo-Hua

  公开号：US20100081669A1

  公开（公告）日：2010-04-01

  Disclosed is a pressure-sensitive adhesive matrix patch device for treatment or prevention of fungal toenails or fingernails or foot infections comprising an antifungal agent or two or more antifungals in combination and adhesively secured to a dorsal site of an infected palm or foot, rather than an area of infection and surrounding skin. A method for the transdermal treatment or prevention of fungal toenails or fingernails or foot infections with an antifungal agent is also disclosed, the method comprising adhesively securing to a dorsal site of an infected palm or foot a pressure-sensitive adhesive matrix patch device for a time sufficient to deliver an effective amount of the antifungal agent to an area of infection.
• US5583136A
  申请人：——

  公开号：US5583136A

  公开（公告）日：1996-12-10
• US9308203B2
  申请人：——

  公开号：US9308203B2

  公开（公告）日：2016-04-12