3-Piperidinol, 4,4-dimethyl- | 955082-91-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-Piperidinol, 4,4-dimethyl-
• 英文别名: 4,4-dimethylpiperidin-3-ol
• CAS: 955082-91-4
• 化学式: C₇H₁₅NO
• 分子量: 129.2
• InChiKey: HQLSXLMTYLOKHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• BICYCLIC COMPOUNDS AS PIM INHIBITORS
  申请人：Wang Hui-Ling

  公开号：US20140031360A1

  公开（公告）日：2014-01-30

  The invention relates to bicyclic compounds of formula (1′), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

  本发明涉及公式（1'）的双环化合物及其盐。在某些实施例中，本发明涉及Pim-1和/或Pim-2和/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。在更进一步的实施例中，本发明涉及包含所披露化合物的制药组合物及其在预防和治疗Pim激酶相关疾病和病症，尤其是癌症方面的应用。
• [EN] BICYCLIC COMPOUNDS AS PIM INHIBITORS<br/>[FR] COMPOSÉS BICYCLIQUES EN TANT QU'INHIBITEURS DE PIM
  申请人：AMGEN INC

  公开号：WO2012078777A1

  公开（公告）日：2012-06-14

  The invention relates to bicyclic compounds of formula (1'), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

  本发明涉及公式（1'）的双环化合物及其盐。在某些实施例中，本发明涉及Pim-1和/或Pim-2以及/或Pim-3蛋白激酶活性或酶功能的抑制剂或调节剂。在更进一步的实施例中，本发明涉及包含所述化合物的制药组合物以及它们在预防和治疗与Pim激酶相关的疾病和病症，尤其是癌症方面的应用。
• Bicyclic compounds as Pim inhibitors
  申请人：Amgen Inc.

  公开号：EP2796456A1

  公开（公告）日：2014-10-29

  The invention relates to bicyclic compounds of formula 2' and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.

  本发明涉及式 2'的双环化合物及其盐类。 在某些实施方案中，本发明涉及 Pim-1 和/或 Pim-2 和/或 Pim-3 蛋白激酶活性或酶功能的抑制剂或调节剂。在更进一步的实施方案中，本发明涉及包含本文公开的化合物的药物组合物，以及它们在预防和治疗与Pim激酶相关的病症和疾病（优选癌症）中的用途。
• DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2010506B1

  公开（公告）日：2010-08-04
• US9090593B2
  申请人：——

  公开号：US9090593B2

  公开（公告）日：2015-07-28