1-{-2-[3-(3,4-dimethoxyphenyl)-5,6-dimethoxy-2-methoxymethyl-indan-1-yl]-ethyl}-4-(4-methoxyphenyl)-piperazine | 412315-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-{-2-[3-(3,4-dimethoxyphenyl)-5,6-dimethoxy-2-methoxymethyl-indan-1-yl]-ethyl}-4-(4-methoxyphenyl)-piperazine
• 英文别名: 1-[2-[3-(3,4-dimethoxyphenyl)-5,6-dimethoxy-2-(methoxymethyl)-2,3-dihydro-1H-inden-1-yl]ethyl]-4-(4-methoxyphenyl)piperazine
• CAS: 412315-46-9
• 化学式: C₃₄H₄₄N₂O₆
• 分子量: 576.733
• InChiKey: IJNJOQORSHWDHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  42
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  61.9
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Aryl-indane compounds
  申请人：——

  公开号：US20020128231A1

  公开（公告）日：2002-09-12

  A new family of compounds, particularly aryl-indane compounds, is disclosed. The compounds may be used as inhibitors of P-glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resistance to chemotherapeutic agents is disclosed.

  揭示了一类新的化合物家族，特别是芳基茚烷化合物。这些化合物可用作P-糖蛋白介导的转运抑制剂。揭示了利用这些化合物来增强生物利用度并调节多药耐药性对化疗药物的作用。
• [EN] ARYL-INDANE COMPOUNDS<br/>[FR] COMPOSES ARYLINDANES
  申请人：AVLAN LTD

  公开号：WO2002030915A2

  公开（公告）日：2002-04-18

  A new family of compounds, particularly aryl-indane compounds, is disclosed. The compounds may be used as inhibitors of P-glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resistance to chemotherapeutic agents is disclosed.