4-methyl-3,4-dihydro-2H-1-benzothiopyran 1,1-dioxide | 332885-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 4-methyl-3,4-dihydro-2H-1-benzothiopyran 1,1-dioxide
• 英文别名: 2H-1-Benzothiopyran, 3,4-dihydro-4-methyl-, 1,1-dioxide；4-methyl-3,4-dihydro-2H-thiochromene 1,1-dioxide
• CAS: 332885-73-1
• 化学式: C₁₀H₁₂O₂S
• 分子量: 196.27
• InChiKey: RPAVCRAYQMOMIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(1-methylethenyl)-2-(methylsulfonyl)benzene 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以25%的产率得到4-methyl-3,4-dihydro-2H-1-benzothiopyran 1,1-dioxide
  参考文献：
  名称：

  An Efficient Synthesis of 4-Mono- and 4,4-Di-substituted 3,4-Dihydro-2H-1-benzothiopyran 1,1-Dioxides by LDA-Mediated Cyclization of o-(Methylsulfonyl)styrenes

  摘要：

  A new and efficient method for the preparation of 3,4-dihydro-2H-1-benzothiopyran 1,1-dioxide derivatives has been developed. alpha-Substituted o-(methylsulfonyl)styrenes, which can be derived from alpha-substituted o-bromostyrenes by an easily operated two-step sequence, are cyclized on treatment with lithium diisopropylamide (LDA) to give, after aqueous workup, the corresponding 4-monosubstituted 3,4-dihydro-2H-1-benzothiopyran 1,1-dioxides. Addition of electrophiles prior to aqueous workup provides 4,4-disubstituted derivatives.

  DOI：

  10.3987/com-18-13959

文献信息

• FUNGICIDE N-CYCLOALKYL-N-BICYCLIC-CARBOXAMIDE DERIVATIVES
  申请人：Desbordes Philippe

  公开号：US20100197925A1

  公开（公告）日：2010-08-05

  The present invention relates N-cycloalkyl-N-bicyclic-carboxamide, thiocarboxamide or N-substituted carboximidamide derivatives of formula (I) wherein A represents a carbo-linked, 5-membered heterocyclyl group; T represents O, S, N—R a , N—OR a , N—NR a R b or N—CN; Z 1 represents a C 3 -C 7 -cycloalkyl group; X represents N or a CZ 7 and Z 2 ; Z 3 ; L 1 and L 2 represent various substituents; their process of preparation; preparation intermediate compounds; their use as fungicide active agents, particularly in the form of fungicide compositions and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

  本发明涉及公式（I）的N-环烷基-N-双环羧酰胺，硫代羧酰胺或N-取代羧酰亚胺衍生物，其中A代表一个与碳原子相连的五元杂环基团；T代表O，S，N—Ra，N—ORa，N—NRaRb或N—CN；Z1代表一个C3-C7环烷基团；X代表N或CZ7和Z2；Z3，L1和L2代表各种取代基；其制备方法；制备中间化合物；其用作杀真菌剂活性剂，特别是以杀真菌剂组成物的形式和使用这些化合物或组合物控制植物病原真菌，特别是植物的方法。
• IMINOPYRIDINE DERIVATIVE AND USE THEREOF
  申请人：Yoshida Masato

  公开号：US20110039892A1

  公开（公告）日：2011-02-17

  The present invention aims to provide a compound having a superior selective α 1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like. The present invention provides a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

  本发明旨在提供一种化合物，具有优异的选择性α1D肾上腺素能受体拮抗作用，并且可用作预防或治疗下尿路疾病等药物。本发明提供一种由式(I)表示的化合物或其盐，其中每个符号如规范中所定义。
• INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR
  申请人：Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

  公开号：EP3489233B1

  公开（公告）日：2022-01-12
• US8334390B2
  申请人：——

  公开号：US8334390B2

  公开（公告）日：2012-12-18
• US8674095B2
  申请人：——

  公开号：US8674095B2

  公开（公告）日：2014-03-18