benzyl N-(6-phenyl-6-azaspiro[2.5]octan-2-yl)carbamate | 1371989-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: benzyl N-(6-phenyl-6-azaspiro[2.5]octan-2-yl)carbamate
• CAS: 1371989-65-9
• 化学式: C₂₁H₂₄N₂O₂
• 分子量: 336.434
• InChiKey: VDVJDDMPVSYSLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Ethyl 6-phenyl-6-azaspiro[2.5]octane-2-carboxylate 在 N,N-二异丙基乙胺 、 lithium hydroxide 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 生成 benzyl N-(6-phenyl-6-azaspiro[2.5]octan-2-yl)carbamate
  参考文献：
  名称：

  可用作钠通道阻滞剂的环丙基-螺-哌啶：专利亮点。

  摘要：

  DOI：

  10.1021/ml300195b

文献信息

• [EN] CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS<br/>[FR] CYCLOPROPYL-SPIRO-PIPÉRIDINES UTILES COMME BLOQUEURS DES CANAUX SODIQUES
  申请人：SCHERING CORP

  公开号：WO2012047703A2

  公开（公告）日：2012-04-12

  Cyclopropyl-spiro-piperidine compounds represented by Formulas (I)-(III) or pharmaceutically acceptable salts thereof, are blockers of voltage-gated sodium channels. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, voltage-gated sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy or epilepsy conditions, irritable bowel syndrome, depression, anxiety, bipolar disorder, neurodegenerative disorders, psychiatric disorders, myotonia, arrhythmia, movement disorders, neuroendocrine disorders, ataxia, multiple sclerosis, irritable bowel syndrome, incontinence, neuropathy and tinnitus, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
• Cyclopropyl-<i>spiro</i>-piperidines Useful as Sodium Channel Blockers
  作者：Benjamin Blass

  DOI：10.1021/ml300195b

  日期：2012.9.13