1-(4-Methoxyphenyl)-4-(2,4,6-trimethoxyphenyl)piperidin-3-ol | 647020-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-Methoxyphenyl)-4-(2,4,6-trimethoxyphenyl)piperidin-3-ol
• CAS: 647020-66-4
• 化学式: C₂₁H₂₇NO₅
• 分子量: 373.4
• InChiKey: FJXYJABLLVYJAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,2,3,6-Tetrahydro-1-(4-methoxyphenyl)-4-(2,4,6-trimethoxyphenyl)pyridine 、 硼氢化钠 、 三氟化硼 、 四氢呋喃 在 boron dimer 、 水 、 盐酸 、 双氧水 作用下， 反应 2.0h， 生成 1-(4-Methoxyphenyl)-4-(2,4,6-trimethoxyphenyl)piperidin-3-ol
  参考文献：
  名称：

  Inhibitors of cyclin dependent kinases and their use

  摘要：

  本发明涉及一种新的化合物，用于抑制细胞周期依赖性激酶，更具体地，涉及公式（Ic）的香豆酮衍生物，其中R1、R2、R3、R4、R5、R6、R7和A具有所述权利要求中指示的含义。本发明还涉及制备公式（Ia）化合物的方法，抑制细胞周期依赖性激酶和抑制细胞增殖的方法，使用公式（Ic）化合物治疗和预防可以通过抑制细胞周期依赖性激酶如癌症等疾病的方法，使用公式（Ic）化合物制备应用于此类疾病的药物。本发明还涉及包含公式（Ic）化合物的组合物，单独或与另一活性剂组合，与惰性载体混合或与其它药物助剂一起使用的组合物，特别是包含公式（Ic）化合物的药物组合物，单独或与另一活性剂组合，以及与药物可接受的载体物质和辅助物质相关的制药组合物。

  公开号：

  US07884127B2

文献信息

• Inhibitors of cyclin-dependent kinases and their use
  申请人：——

  公开号：US20040106581A1

  公开（公告）日：2004-06-03

  The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing a compound of formula (Ia) either alone or in combination with another active agent, in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula (Ia) either alone or in combination with another active agent, together with pharmaceutically acceptable carrier substances and auxiliary substances.

  本发明涉及一种新型化合物，用于抑制细胞周期蛋白依赖性激酶，尤其是公式（Ia）的香豆素衍生物，其中R1、R2、R3、R4、R5、R6、R7和A的含义如权利要求中所示。本发明还涉及制备公式（Ia）化合物的方法，抑制细胞周期蛋白依赖性激酶和细胞增殖的方法，使用公式（Ia）化合物治疗和预防由于细胞周期蛋白依赖性激酶抑制而可以治疗或预防的疾病，如癌症，使用公式（Ia）化合物制备用于治疗此类疾病的药物。本发明还涉及含有公式（Ia）化合物的组合物，单独或与另一活性剂结合，与惰性载体混合或以其他方式结合，特别是含有公式（Ia）化合物的药物组合物，单独或与另一活性剂结合，与药用可接受载体物质和辅助物质一起使用的制剂。
• INHIBITORS OF CYCLIN DEPENDENT KINASES AND THEIR USE
  申请人：Lal Bansi

  公开号：US20070015802A1

  公开（公告）日：2007-01-18

  The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ic) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ic) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ic) in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing a compound of formula (Ic) either alone or in combination with another active agent, in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula (Ic) either alone or in combination with another active agent, together with pharmaceutically acceptable carrier substances and auxiliary substances.

  本发明涉及一种新型化合物，用于抑制细胞周期蛋白依赖性激酶，特别是公式(Ic)的香豆素衍生物，其中R1、R2、R3、R4、R5、R6、R7和A的含义如权利要求所示。本发明还涉及制备公式(Ia)化合物的方法，抑制细胞周期蛋白依赖性激酶和抑制细胞增殖的方法，以及使用公式(Ic)化合物在治疗和预防细胞周期蛋白依赖性激酶抑制剂可治疗或预防的疾病，如癌症，以及使用公式(Ic)化合物制备应用于这些疾病的药物。本发明还涉及含有公式(Ic)化合物的组合物，单独或与另一种活性剂联合使用，与惰性载体混合或以其他方式与惰性载体相结合，特别是含有公式(Ic)化合物的药物组合物，单独或与另一种活性剂联合使用，以及与药用载体物质和辅助物质相结合。
• Inhibitors of Cyclin Dependent Kinases and Their Use
  申请人：Lal Bansi

  公开号：US20110136873A1

  公开（公告）日：2011-06-09

  The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing a compound of formula (Ia) either alone or in combination with another active agent, in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula (Ia) either alone or in combination with another active agent, together with pharmaceutically acceptable carrier substances and auxiliary substances.

  本发明涉及新型化合物，用于抑制细胞周期蛋白依赖性激酶，更具体地说，涉及公式(Ia)的香豆酮衍生物，其中R1、R2、R3、R4、R5、R6、R7和A具有所述权利要求中指示的含义。本发明还涉及制备公式(Ia)化合物的方法，抑制细胞周期蛋白依赖性激酶和抑制细胞增殖的方法，以及使用公式(Ia)化合物治疗和预防通过抑制细胞周期蛋白依赖性激酶治疗或预防的疾病，如癌症，使用公式(Ia)化合物制备应用于此类疾病的药物。本发明还涉及含有公式(Ia)化合物的组合物，单独或与另一活性剂混合，与惰性载体混合或以其他方式与惰性载体相关联，特别是含有公式(Ia)化合物的制药组合物，单独或与另一活性剂混合，以及与药物可接受的载体物质和辅助物质一起使用。
• INHIBITORS OF CYCLIN-DEPENDENT KINASES AND THEIR USE
  申请人：Lal Bansi

  公开号：US20130045993A1

  公开（公告）日：2013-02-21

  The present invention relates to novel compounds for the inhibition of cyclindependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclindependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases. The invention further relates to compositions containing a compound of formula (Ia) either alone or in combination with another active agent, in admixture or otherwise in association with an inert carrier, in particular pharmaceutical compositions containing a compound of formula (Ia) either alone or in combination with another active agent, together with pharmaceutically acceptable carrier substances and auxiliary substances.

  本发明涉及新型化合物，用于抑制细胞周期依赖性激酶，特别是公式(Ia)的香豆酮衍生物，其中R1、R2、R3、R4、R5、R6、R7和A具有所述权利要求中指定的含义。本发明还涉及制备公式(Ia)化合物的方法，抑制细胞周期依赖性激酶和抑制细胞增殖的方法，以及使用公式(Ia)化合物治疗和预防可通过抑制细胞周期依赖性激酶如癌症等疾病的用途，以及使用公式(Ia)化合物制备应用于此类疾病的药物。本发明还涉及含有公式(Ia)化合物的组合物，单独或与另一种活性剂混合，与惰性载体混合或以其他方式联合，特别是含有公式(Ia)化合物的药物组合物，单独或与另一种活性剂混合，以及与药用载体物质和辅助物质混合。
• FLAVONE DERIVATIVES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES
  申请人：Nicholas Piramal India Limited

  公开号：EP1556375A2

  公开（公告）日：2005-07-27