2-(pyridine-4-yl)oxazolo[4,5-b]pyridine | 52333-72-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶唑并吡啶类
• 英文名称: 2-(pyridine-4-yl)oxazolo[4,5-b]pyridine
• 英文别名: 2-Pyrid-4-yloxazolo<4,5-b>pyridin；2-pyridin-4-yl-oxazolo[4,5-b]pyridine；2-(4-Pyridinyl)oxazolo[4,5-b]pyridine；2-pyridin-4-yl-[1,3]oxazolo[4,5-b]pyridine
• CAS: 52333-72-9
• 化学式: C₁₁H₇N₃O
• 分子量: 197.196
• InChiKey: JIZWSKGUJOYVOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(3-hydroxypyridin-2-yl)pyridine-4-carboxamide 在 Al³⁺ exchanged K₁₀ clay 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 16.0h， 以90%的产率得到2-(pyridine-4-yl)oxazolo[4,5-b]pyridine
  参考文献：
  名称：

  A green route for the synthesis of 2-substituted benzoxazole derivatives catalyzed by Al3+-exchanged K10 clay

  摘要：

  A new, simple, and efficient protocol is developed for the synthesis of 2-substituted benzoxazole derivatives through N-C-O bond formation using Al3+-exchanged K10 clay (Al3+-K10) as catalyst. A wide range of benzoxazole derivatives are synthesized in high yields without affecting many functional groups. Hot filtration experiments showed the absence of metal leaching and catalyst can be reused for five times with only a slight decrease in yield. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.09.039