methyl (3RS,4RS)-1-(tert-butyloxycarbonyl)-4-allylpiperidine-3-carboxylate | 917343-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: methyl (3RS,4RS)-1-(tert-butyloxycarbonyl)-4-allylpiperidine-3-carboxylate
• 英文别名: 1-tert-butyl 3-methyl 4-allylpiperidine-1,3-dicarboxylate；methyl 1-(tert-butyloxycarbonyl)-4allylpiperidine-3-carboxylate；1-O-tert-butyl 3-O-methyl 4-prop-2-enylpiperidine-1,3-dicarboxylate
• CAS: 917343-18-1
• 化学式: C₁₅H₂₅NO₄
• 分子量: 283.368
• InChiKey: JWSADIIZCQZRMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl (3RS,4RS)-1-(tert-butyloxycarbonyl)-4-allylpiperidine-3-carboxylate 在 三乙胺 、 9-硼双环[3.3.1]壬烷 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 1-tert-butyl 3-methyl 4-{3-[(methylsulfonyl)oxy]propyl}piperidine-1,3-dicarboxylate
  参考文献：
  名称：

  WO2006/134378

  摘要：

  公开号：

文献信息

• Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them
  申请人：——

  公开号：US20020177606A1

  公开（公告）日：2002-11-28

  Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described. 1

  描述了一般式(I)的喹诺啉基丙基哌啶衍生物，并且它们可用作抗微生物剂。同时也描述了它们的制备方法。
• Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor
  申请人：——

  公开号：US20040082610A1

  公开（公告）日：2004-04-29

  Quinolylpropylpiperidine derivatives of general formula (I) in which R 1a is hydrogen, halogen, hydroxyl, amino, alkylamino, dialkylamino, hydroxyamino, alkoxyamino or alkylalkoxyamino and R 1b is hydrogen, or R 1a and R 1b form an oxo, R 2 is carboxyl, carboxymethyl or hydroxymethyl, R 3 is alkyl either substituted with phenylthio optionally substituted with halogen, hydroxyl, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkoxycarbonyl, cyano or amino, or with cycloalkylthio (3 to 7 members) optionally substituted with halogen or trifluoromethyl, or with heteroarylthio (5 to 6 members and 1 to 4 heteroatoms chosen from N, O and S), optionally substituted with halogen, hydroxyl, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkoxycarbonyl, cyano or amino or R 3 is propargyl substituted with phenyl or heteroaryl as defined above, R 4 is alkyl, alkenyl-CH 2 — or alkynyl-CH 2 —, cycloalkyl or cycloalkylalkyl, in their various isomeric forms, separate or as mixtures, and also their salts, their preparation process and intermediates and the compositions containing them. These novel derivatives are potent antibacterial agents. 1

  通式（I）的喹诺啉基丙基哌啶衍生物，其中R1a为氢、卤素、羟基、氨基、烷基氨基、二烷基氨基、羟基氨基、烷氧基氨基或烷基氧基氨基，R1b为氢，或R1a和R1b形成氧代基，R2为羧基、羧甲基或羟甲基，R3为烷基，或被苯硫氧基取代的烷基，该苯硫氧基可选择卤素、羟基、烷基、烷氧基、三氟甲基、三氟甲氧基、羧基、烷氧羰基、氰基或氨基进行取代，或被环状烷硫氧基（3到7个成员）取代，该环状烷硫氧基可选择卤素或三氟甲基进行取代，或被杂环芳硫氧基（5到6个成员和1到4个从N、O和S中选择的杂原子）取代，该杂环芳硫氧基可选择卤素、羟基、烷基、烷氧基、三氟甲基、三氟甲氧基、羧基、烷氧羰基、氰基或氨基进行取代，或R3为丙炔基，被定义如上的苯基或杂环芳基取代，R4为烷基、烯基-CH2-或炔基-CH2-、环状烷基或环状烷基烷基，在它们的各种同分异构体形式中，分离或混合，以及它们的盐、它们的制备过程和中间体以及含有它们的组合物。这些新的衍生物是有效的抗菌剂。
• Compounds for the treatment of multi-drug resistant bacterial infections
  申请人：AstraZeneca AB

  公开号：US07875715B2

  公开（公告）日：2011-01-25

  The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.

  本发明涉及表现出抗菌活性的化合物，其制备过程，含有其作为活性成分的药物组合物，以及它们作为药物的使用和用于制造用于治疗温血动物（如人类）细菌感染的药物的使用。特别地，本发明涉及用于治疗温血动物（如人类）细菌感染的有用化合物，更具体地涉及这些化合物用于制造用于治疗温血动物（如人类）细菌感染的药物。
• COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS
  申请人：Breault Gloria

  公开号：US20110092495A1

  公开（公告）日：2011-04-21

  The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.

  本发明涉及表现出抗菌活性的化合物，其制备过程，含有它们作为活性成分的制药组合物，它们作为药物的使用以及它们在制造用于治疗温血动物（如人类）细菌感染的药物中的使用。特别是本发明涉及用于治疗温血动物（如人类）细菌感染的有用化合物，更具体地涉及这些化合物在制造用于治疗温血动物（如人类）细菌感染的药物中的使用。
• US6841562B2
  申请人：——

  公开号：US6841562B2

  公开（公告）日：2005-01-11