tert-butyl 4-(guanidinomethyl)piperidine-1-carboxylate hydrochloride | 1246547-67-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 4-(guanidinomethyl)piperidine-1-carboxylate hydrochloride
• 英文别名: Tert-butyl 4-(carbamimidamidomethyl)piperidine-1-carboxylate；tert-butyl 4-[(diaminomethylideneamino)methyl]piperidine-1-carboxylate;hydrochloride
• CAS: 1246547-67-0
• 化学式: C₁₂H₂₄N₄O₂*ClH
• 分子量: 292.809
• InChiKey: YNPZUCNPYPHIFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.54
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  95.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-1-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-3-(dimethylamino)prop-2-en-1-one 、 tert-butyl 4-(guanidinomethyl)piperidine-1-carboxylate hydrochloride 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 48.0h， 生成 tert-butyl 4-(((4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrimidin-2-yl)amino)methyl)piperidine-1-carboxylate
  参考文献：
  名称：

  Substituted Heterocyclic Compounds

  摘要：

  本发明涉及替代杂环化合物及其合成方法。本发明还涉及含有替代杂环化合物的药物组合物以及通过向需要的受试者投与这些化合物和药物组合物来治疗细胞增殖性疾病，如癌症的方法。

  公开号：

  US20110160237A1

文献信息

• SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS
  申请人：Tandon Manish

  公开号：US20100249108A1

  公开（公告）日：2010-09-30

  The present invention relates to substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物以及合成这些化合物的方法。本发明还涉及含有取代的二吡咯-嘧啶-二氮杂环化合物，取代的苯并-二吡咯-嘧啶-二氮杂环化合物的药物组合物，并通过将这些化合物和药物组合物给予需要的受体中，治疗细胞增殖性疾病，如癌症的方法。
• US8349827B2
  申请人：——

  公开号：US8349827B2

  公开（公告）日：2013-01-08
• US8563567B2
  申请人：——

  公开号：US8563567B2

  公开（公告）日：2013-10-22
• [EN] SUBSTITUTED DIPYRIDO-PYRIMIDO-DIAZEPINE AND BENZO-PYRIDO-PYRIMIDO COMPOUNDS<br/>[FR] COMPOSÉS DIPYRIDO-PYRIMIDO-DIAZÉPINE ET BENZO-PYRIDO-PYRIMIDO SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2010114898A1

  公开（公告）日：2010-10-07

  The present invention relates to substituted dipyrido-pyrimido-diazepine compounds of formula (I), substituted benzo-pyrido-pyrimido-diazepine compounds of formula (I) and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
• [EN] SUBSTITUTED HETEROCYCLIC COMPOUNDS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES SUBSTITUÉS
  申请人：ARQULE INC

  公开号：WO2011082266A2

  公开（公告）日：2011-07-07

  The present invention relates to substituted heterocyclic compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted heterocyclic compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.