6-(4-ethylpiperazine-1-yl)-N-(6-methylpyridine-2-yl)nicotinamide | 1258161-29-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-(4-ethylpiperazine-1-yl)-N-(6-methylpyridine-2-yl)nicotinamide
• 英文别名: 6-(4-ethylpiperazin-1-yl)-N-(6-methylpyridin-2-yl)pyridine-3-carboxamide
• CAS: 1258161-29-3
• 化学式: C₁₈H₂₃N₅O
• 分子量: 325.414
• InChiKey: QDMGCJDTYGELQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  61.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NEW NICOTINAMIDE DERIVATIVES WITH ANTI-ANDROGEN EFFECTS, PROCESSES OF PREPARING, AND ANTIANDROGENS COMPRISING THE SAME<br/>[FR] NOUVEAUX DÉRIVÉS DE NICOTINAMIDE AYANT DES EFFETS ANTI-ANDROGÉNIQUES, PROCÉDÉS DE PRÉPARATION, ET ANTI-ANDROGÈNES LES COMPRENANT
  申请人：UNIV NAT CHONNAM IND FOUND

  公开号：WO2010143803A2

  公开（公告）日：2010-12-16

  Provided are novel nicotinamide derivatives and pharmaceutically acceptable salts thereof with anti-androgen effects, preparing processes of the same and antiandrogens containing the same as active ingredients. More particularly, the said nicotinamide derivatives have anti-androgen activity, so that they can be effectively used as a preventive or therapeutic agent for androgen-related diseases such as prostatic disease, androgenic alopecia and acne.