2-amino-2-(5-(5-(1-admantyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol hydrochloride | 1608144-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2-amino-2-(5-(5-(1-admantyl)-1,2,4-oxadiazol-3-yl)benzofuran-2-yl)propane-1,3-diol hydrochloride
• 英文别名: 2-[5-[5-(1-Adamantyl)-1,2,4-oxadiazol-3-yl]-1-benzofuran-2-yl]-2-aminopropane-1,3-diol;hydrochloride
• CAS: 1608144-27-9
• 化学式: C₂₃H₂₇N₃O₄*ClH
• 分子量: 445.946
• InChiKey: FUANRVPDQCSNES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.51
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• S1P Receptors Modulators and Their Use Thereof
  申请人：Gill Gurmit S.

  公开号：US20110318388A1

  公开（公告）日：2011-12-29

  The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.

  本发明涉及具有S1P受体调节活性的新化合物。此外，本发明涉及包括本发明中至少一种化合物的药物，用于治疗由不适当的S1P受体调节活性或表达引起或相关的疾病和/或病情，例如自身免疫反应。本发明的另一个方面涉及使用包括本发明中至少一种化合物的药物制造药物，用于治疗由不适当的S1P受体调节活性或表达引起或相关的疾病和/或病情，例如自身免疫反应。