N-[3-(3-fluoro-4-piperazin-1-ylphenyl)isoxazol-5-ylmethyl]acetamide | 1159507-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-[3-(3-fluoro-4-piperazin-1-ylphenyl)isoxazol-5-ylmethyl]acetamide
• 英文别名: N-[[3-(3-fluoro-4-piperazin-1-ylphenyl)-1,2-oxazol-5-yl]methyl]acetamide
• CAS: 1159507-55-7
• 化学式: C₁₆H₁₉FN₄O₂
• 分子量: 318.351
• InChiKey: YVPSNLTZDHMMGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY
  申请人：Hidalgo Rodríguez José

  公开号：US20100075984A1

  公开（公告）日：2010-03-25

  Compounds of formula (I), and their pharmaceutically acceptable salts and solvates, wherein X represents —O—, —NH—, —S—, —NHC(═O)— or —NHC(═S)—; R1 represents —H or a hydrocarbon chain; R2 represents —H, alkoxy, amino, a hydrocarbon chain or a radical of a cycle; R3 represents —H, a hydrocarbon chain or a radical of a cycle; R4 represents —H or a hydrocarbon chain; alternatively R3 and R4 form together a cycle; R5 and R6 represent —H or halogen, and R7 represents —H, a hydrocarbon chain or heteroaryl, are useful against bacterial infections in animals, including humans.