5-Bromobenzofuran-2-sulfonyl chloride | 128852-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 5-Bromobenzofuran-2-sulfonyl chloride
• 英文别名: 5-bromo-1-benzofuran-2-sulfonyl chloride
• CAS: 128852-01-7
• 化学式: C₈H₄BrClO₃S
• 分子量: 295.54
• InChiKey: NKDUUYVUVYWMLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• CHOLESTEROL BIOSYNTHESIS INHIBITORS CONTAINING AS THE ACTIVE INGREDIENT TRICYCLIC SPIRO COMPOUNDS
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1346994A1

  公开（公告）日：2003-09-24

  This invention relates to a cholesterol biosynthesis inhibiting drug by including a tricyclic compounds having spiro union represented by the following formula (I) or its salt as an ingredient, which can be administered orally and which exhibits potent serum cholesterol decreasing action. In the formula, A is a 5-, 6-membered cyclic hydrocarbon group, or the like; B is a single bond, a carbonyl group, or the like; D is a hydrogen atom, or the like; X is a nitrogen atom or the like; Y is an oxygen atom, -NH-, or the like; Z is a methylene group, a carbonyl group, or the like; T is -S(O)z-, a carbonyl group, or the like; Q is a hydrocarbon group, a heterocyclic group, or the like;    l, m and n are independently an integer selected from 0-2 with the proviso that 1 and m are not simultaneously 0; and r is an integer of 0 or 1.

  本发明涉及一种抑制胆固醇生物合成的药物，其成分包括具有下式（I）所代表的螺联的三环化合物或其盐，可口服给药，具有强效降低血清胆固醇的作用。 式中，A 是 5、6 元环状烃基或类似物；B 是单键、羰基或类似物；D 是氢原子或类似物；X 是氮原子或类似物；Y 是氧原子、-NH- 或类似物；Z 是亚甲基、羰基或类似物；T 是-S(O)z-、羰基或类似物；Q 是烃基、杂环基或类似物； l、m 和 n 分别是选自 0-2 的整数，但 1 和 m 不能同时为 0；以及 r 是 0 或 1 的整数。