| 1146664-15-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• CAS: 1146664-15-4
• 化学式: C₁₇H₂₇N₃O₂
• 分子量: 305.42
• InChiKey: FNJNDCUGCZAXII-ZDUSSCGKSA-N

物化性质

• 沸点：
  426.6±35.0 °C(Predicted)
• 密度：
  1.091±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  、 2,4-二氯苯甲酰氯 在 N,N-二异丙基乙胺 作用下， 生成
  参考文献：
  名称：

  Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

  摘要：

  Glycine transporter 1 (GlyT1) represents a novel target for the treatment of schizophrenia via the potentiation of glutamatergic NMDA receptors. The discovery of 4,4-disubstituted piperidine inhibitors of GlyT1 which exhibit improved pharmacokinetic properties, including oral bioavailability, is discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.015
• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 、
  参考文献：
  名称：

  Discovery of GlyT1 inhibitors with improved pharmacokinetic properties

  摘要：

  Glycine transporter 1 (GlyT1) represents a novel target for the treatment of schizophrenia via the potentiation of glutamatergic NMDA receptors. The discovery of 4,4-disubstituted piperidine inhibitors of GlyT1 which exhibit improved pharmacokinetic properties, including oral bioavailability, is discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.01.015