2-(4-methylpiperazin-1-yl)-N-phenyl-N-(piperidin-4-yl)acetamide | 1186213-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-methylpiperazin-1-yl)-N-phenyl-N-(piperidin-4-yl)acetamide
• 英文别名: 2-(4-methylpiperazin-1-yl)-N-phenyl-N-piperidin-4-ylacetamide
• CAS: 1186213-13-7
• 化学式: C₁₈H₂₈N₄O
• 分子量: 316.447
• InChiKey: SYYGLWDSHGOXNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  38.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CYCLIC AMINOALKYLCARBOXAMIDE DERIVATIVE
  申请人：Ozawa Michinori

  公开号：US20100179118A1

  公开（公告）日：2010-07-15

  The present invention relates to a compound represented by the following formula (I), which is useful as an antiallergic agent and/or an anti-inflammatory agent, or a physiologically acceptable salt thereof and the like: wherein R 1 and R 2 are the same or different and each is an optionally substituted aryl group and the like, R 3 is a hydrogen atom, a C 1-6 alkyl group and the like, R 4 and R 5 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxy group, a C 1-6 alkyl group and the like, X is a single bond or —C(R 6 )(R 7 )—, R 6 and R 7 are the same or different and each is a hydrogen atom, a halogen atom, an optionally substituted C 1-6 alkyl group and the like, or R 6 and R 7 optionally form, together with the carbon atom bonded thereto, an optionally substituted C 3-8 cycloalkyl group and the like, ring group A is an azetidin-1-yl group and the like, m is 0, 1 or 2, and n is 0, 1 or 2.

  本发明涉及以下式（I）所表示的化合物或其生理上可接受的盐等，其可用作抗过敏剂和/或抗炎剂： 其中，R1和R2相同或不同，每个都是可选取的取代芳基基团等；R3是氢原子、C1-6烷基基团等；R4和R5相同或不同，每个都是氢原子、卤原子、羟基、C1-6烷基基团等；X是单键或—C(R6)(R7)—；R6和R7相同或不同，每个都是氢原子、卤原子、可选取的取代C1-6烷基基团等，或R6和R7可选择性地与与其相连的碳原子一起形成可选取的取代C3-8环烷基团等；环基团A是氮杂环丙烷基团等；m为0、1或2；n为0、1或2。