3-propyl-6-methyl-1,2,4-benzothiadiazine-1,1-dioxide | 73283-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 3-propyl-6-methyl-1,2,4-benzothiadiazine-1,1-dioxide
• 英文别名: 6-methyl-3-propyl-4H-1lambda6,2,4-benzothiadiazine 1,1-dioxide；6-methyl-3-propyl-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide
• CAS: 73283-43-9
• 化学式: C₁₁H₁₄N₂O₂S
• 分子量: 238.31
• InChiKey: FFBZLFOCHFXVJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel compounds and their use as positive AMPA receptor modulators
  申请人：Neurosearch A/S.

  公开号：US20040043987A1

  公开（公告）日：2004-03-04

  The invention provides novel compounds represented by the general formula 5 compound represented by the formula: 1 wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R 2 ; X represents SO 2 or C═O or CH 2 ; Y represents —CH(R 4 )—, —N(R 4 )— or —N(R 4 )—CH 2 —, O; and the meaning of R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and R 8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.

  该发明提供了一种新型化合物，其通式5的化合物如下所示：其中由虚线表示的键可以是单键、双键或不存在；如果键不存在，则氮原子用氢和R2取代；X代表SO2或C═O或CH2；Y代表—CH(R4)—、—N(R4)—或—N(R4)— —、O；R2、R3、R4、R5、R6、R7和R8的含义如申请中所定义。这些化合物可用作AMPA受体的阳性调节剂。
• Hair growth stimulation with nitroxide and other radicals
  申请人：PROCTOR, Peter H.

  公开号：EP0327263A1

  公开（公告）日：1989-08-09

  Hair growth stimulation with nitroxide and other radicals. A nitroxide radical source compound is applied topically with an adjuvant selected from reducing agents, hydroxyl radical scavengers and antioxidants to activate formation of the nitroxide radical and/or to protect the nitroxide radical from reaction with other free radicals. Also disclosed is a kit for preparing a unit dose for topical application of a nitric oxide generating compound and a reducing agent reactive therewith to form nitric oxide on or in the skin. Other adjuvants include SOD and antiandrogens. Various other radical-­forming hair growth stimulants and preparations thereof are disclosed.

  用亚硝基和其他自由基刺激头发生长。一氧化氮自由基源化合物与选自还原剂、羟自由基清除剂和抗氧化剂的辅助剂一起局部施用，以激活一氧化氮自由基的形成和/或保护一氧化氮自由基不与其他自由基发生反应。 还公开了一种试剂盒，用于制备单位剂量的一氧化氮生成化合物和与之反应在皮肤上或皮肤内形成一氧化氮的还原剂，供局部使用。其他辅助剂包括 SOD 和抗雄激素。还公开了其他各种自由基生发刺激剂及其制剂。
• NOVEL COMPOUNDS AND THEIR USE AS POSITIVE AMPA RECEPTOR MODULATORS
  申请人：NEUROSEARCH A/S

  公开号：EP1071426A2

  公开（公告）日：2001-01-31
• US6943159B1
  申请人：——

  公开号：US6943159B1

  公开（公告）日：2005-09-13
• US7235548B2
  申请人：——

  公开号：US7235548B2

  公开（公告）日：2007-06-26