[cis-4-(4-isopropyl-piperazine-1-carbonyl)-cyclohexyl]-carbamic acid tert-butyl ester | 944404-28-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [cis-4-(4-isopropyl-piperazine-1-carbonyl)-cyclohexyl]-carbamic acid tert-butyl ester
• CAS: 944404-28-8
• 化学式: C₁₉H₃₅N₃O₃
• 分子量: 353.505
• InChiKey: QLZCLDNIBOELHC-IYBDPMFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  61.88
• 氢给体数：
  1.0
• 氢受体数：
  4.0

文献信息

• Cyclohexyl piperazinyl methanone derivatives
  申请人：Nettekoven Matthias

  公开号：US20070167436A1

  公开（公告）日：2007-07-19

  The present invention relates to compounds of formula I wherein s, R 1a and R 1 to R 3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

  本发明涉及公式I的化合物，其中s，R1a和R1到R3如描述和索赔中定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与H3受体调节相关的疾病。
• Cyclohexyl sulfonamide derivatives
  申请人：Nettekoven Matthias

  公开号：US20070173511A1

  公开（公告）日：2007-07-26

  The present invention relates to compounds of formula I wherein R 1 to R 3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

  本发明涉及式I的化合物，其中R1至R3如描述和权利要求所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与H3受体调节相关的疾病。
• CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES
  申请人：Nettekoven Matthias

  公开号：US20100120769A1

  公开（公告）日：2010-05-13

  The present invention relates to compounds of formula I wherein s, R 1a and R 1 to R 3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

  本发明涉及公式I的化合物，其中s，R1a和R1到R3如描述和权利要求中所定义，以及其药学上可接受的盐。这些化合物可用于治疗和/或预防与H3受体调节相关的疾病。
• CYCLOHEXYL SULFONAMIDE DERIVATIVES
  申请人：Nettekoven Matthias

  公开号：US20100120791A1

  公开（公告）日：2010-05-13

  The present invention relates to compounds of formula I wherein R 1 to R 3 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

  本发明涉及公式I中的化合物，其中R1至R3如描述和权利要求中所定义，并且其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体调节相关的疾病。
• CYCLOHEXYL SULFONAMIDE DERIVATIVES HAVING H3 RECEPTOR ACTIVITY
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1979322B1

  公开（公告）日：2010-09-01