Piperazine, 2,5-dimethyl-1-(1-methylethyl)-, (2R,5S)-rel- | 1072102-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Piperazine, 2,5-dimethyl-1-(1-methylethyl)-, (2R,5S)-rel-
• 英文别名: (2R,5S)-2,5-dimethyl-1-propan-2-ylpiperazine
• CAS: 1072102-68-1
• 化学式: C₉H₂₀N₂
• 分子量: 156.27
• InChiKey: ZZMDOTWZZOLFDG-DTWKUNHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS
  申请人：Gilead Sciences, Inc.

  公开号：US20130164280A1

  公开（公告）日：2013-06-27

  The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.

  该发明提供了用于治疗病毒感染的化合物、药物可接受的盐和酯以及它们的组合物。这些化合物和组合物对于治疗包括人类呼吸道合胞病毒感染在内的肺病毒亚科病毒感染是有用的。
• [EN] BENZAMIDE AND NICOTINAMIDE COMPOUNDS AND METHODS OF USING SAME<br/>[FR] BENZAMIDE ET COMPOSÉS DE NICOTINAMIDE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ONCOTARTIS INC

  公开号：WO2015100322A1

  公开（公告）日：2015-07-02

  The present disclosure provides benzamide and nicotinamide compounds and pharmaceutical uses of the compounds. The compounds can be used to treat, for example, cancers such hematopoietic cancers (e.g., leukemia). The preferred compounds of the invention contain a phenylethynyl moiety as well as an amine-based heterocyclyl or heteroaryl moiety attached to the benzamide or nicotinamide compound.

  本公开提供苯甲酰胺和烟酰胺化合物以及这些化合物的药用。这些化合物可用于治疗，例如，血液肿瘤等血液肿瘤（如白血病）。本发明的优选化合物包含苯乙炔基团以及连接到苯甲酰胺或烟酰胺化合物的胺基杂环基团或杂芳基团。
• N-(3,4-disubstituted phenyl) salicylamide derivatives
  申请人：TOKUYAMA Ryukou

  公开号：US20080227784A1

  公开（公告）日：2008-09-18

  A compound represented by the following formula (I) or a salt thereof: wherein R 1 , R 2 , R 3 and R 4 represent hydrogen atom, a halogen atom, cyano group, nitro group, a C 1-4 alkyl group, a halogenated C 1-4 alkyl group or a C 1-4 alkoxy group, R 5 represents a halogen atom, cyano group, a C 1-4 alkyl group, a halogenated C 1-4 alkyl group or a C 1-4 alkoxy group, R 6 represents a C 5-7 cycloalkyl group, a substituted C 5-7 cycloalkyl group, a 5 to 7-membered completely saturated heterocyclic group or a substituted 5 to 7-membered completely saturated heterocyclic group, X represents a single bond, oxygen atom, sulfur atom, NR 7 , —O—CH 2 — or —N(R 8 )—CH 2 —, R 7 represents hydrogen atom or a C 1-4 alkyl group, or R 7 may combine with a substituent of R 6 to represent a single bond, methylene group or ethylene group, R 8 represents hydrogen atom, a C 1-4 alkyl group or a C 7-12 aralkyl group, which is useful as an active ingredient of a medicament for prophylactic and/or therapeutic treatment of diseases caused by an activation of STAT6 and/or NF-κB.

  由以下式（I）表示的化合物或其盐：其中R1、R2、R3和R4代表氢原子、卤原子、氰基、硝基、C1-4烷基、卤代C1-4烷基或C1-4烷氧基，R5代表卤原子、氰基、C1-4烷基、卤代C1-4烷基或C1-4烷氧基，R6代表C5-7环烷基、取代的C5-7环烷基、5至7-成员完全饱和杂环基或取代的5至7-成员完全饱和杂环基，X代表单键、氧原子、硫原子、NR7、—O—CH2—或—N(R8)—CH2—，R7代表氢原子或C1-4烷基，或R7可以与R6的取代基结合以表示单键、亚甲基基团或乙烯基团，R8代表氢原子、C1-4烷基或C7-12芳基烷基，可用作药物的活性成分，用于预防和/或治疗由STAT6和/或NF-κB激活引起的疾病。
• FAST-DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS
  申请人：MacDonald Gregor James

  公开号：US20100069394A1

  公开（公告）日：2010-03-18

  The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.

  本发明涉及4-芳基-6-哌嗪-1-基-3-取代吡啶嗪，它们是快速解离的多巴胺2受体拮抗剂，制备这些化合物的方法，以及包含这些化合物作为活性成分的制药组合物。这些化合物可用作治疗或预防中枢神经系统疾病的药物，例如精神分裂症，通过发挥抗精神病作用而不产生运动副作用。
• 2, 6-NAPHTHRIDINE DERIVATIVES
  申请人：van Eis Maurice

  公开号：US20100130469A1

  公开（公告）日：2010-05-27

  The present invention relates to novel organic compounds comprising a naphthyridine which may be mediators of a selective subset of kinases belonging to the AGC kinase family, such as for example PKC, PKD, PKN-1/2, CDK-9, MRCK-beat, PASK, PRKX, ROCK-I/II or mediators of other kinases, the selectivity of which would be depending on the structural variation thereof.

  本发明涉及一种新的有机化合物，包括一种萘啶，它可能是AGC激酶家族的一种选择性亚组的介质，例如PKC，PKD，PKN-1/2，CDK-9，MRCK-beat，PASK，PRKX，ROCK-I/II或其他激酶的介质，其选择性取决于其结构变化。