methyl N-[[(5S)-3-[3,5-difluoro-4-[4-[2-[[2-(1,2,4-triazol-1-yl)acetyl]amino]acetyl]piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]carbamate | 1227686-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: methyl N-[[(5S)-3-[3,5-difluoro-4-[4-[2-[[2-(1,2,4-triazol-1-yl)acetyl]amino]acetyl]piperazin-1-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]carbamate
• CAS: 1227686-66-9
• 化学式: C₂₂H₂₆F₂N₈O₆
• 分子量: 536.495
• InChiKey: NXTATPVKIKFLGB-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  151
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• US8841306B2
  申请人：——

  公开号：US8841306B2

  公开（公告）日：2014-09-23
• [EN] NOVEL ANTIMICROBIALS<br/>[FR] NOUVEAUX AGENTS ANTIMICROBIENS
  申请人：PANACEA BIOTEC LTD

  公开号：WO2010058423A2

  公开（公告）日：2010-05-27

  The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides,Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.