US9833448, Example 8 from US 2010/0179166 | 1092784-12-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: US9833448, Example 8 from US 2010/0179166
• 英文别名: N-[(6S,9R)-6-(2,3-difluorophenyl)-3-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[c]pyridine]-3'-carboxamide
• CAS: 1092784-12-7
• 化学式: C₃₂H₃₀F₂N₆O₃
• 分子量: 584.625
• InChiKey: IDZRBQDLAOIEQP-MOFPZTFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  43
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• PIPERIDINONE CARBOXAMIDE AZAINDANE CGRP RECEPTOR ANTAGONISTS
  申请人：Bell Ian M.

  公开号：US20120122899A1

  公开（公告）日：2012-05-17

  The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及哌啶酮羧酰胺吖啶衍生物，它们是CGRP受体拮抗剂，可用于治疗或预防CGRP参与的疾病，如偏头痛。该发明还涉及包含这些化合物的药物组合物，以及在预防或治疗CGRP参与的这类疾病中使用这些化合物和组合物。
• Piperidinone carboxamide azaindane CGRP receptor antagonists
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2821407A1

  公开（公告）日：2015-01-07

  The present invention is directed to piperidinone carboxamide azaindane derivatives of formula I which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及式 I 的哌啶酮羧酰胺氮杂茚衍生物，其是 CGRP 受体的拮抗剂，可用于治疗或预防 CGRP 所涉及的疾病，如偏头痛。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗CGRP参与的此类疾病中的用途。
• US8481556B2
  申请人：——

  公开号：US8481556B2

  公开（公告）日：2013-07-09
• US8754096B2
  申请人：——

  公开号：US8754096B2

  公开（公告）日：2014-06-17
• US8912210B2
  申请人：——

  公开号：US8912210B2

  公开（公告）日：2014-12-16