8-(3,5-Difluorophenyl)-8-methyl-10-oxo-N-(1a(2),3a(2),5,7-tetrahydro-2a(2)-oxospiro[6H-cyclopenta[b]pyridine-6,3a(2)-[3H]pyrrolo[2,3-b]pyridin]-3-yl)-6,9-diazaspiro[4.5]decane-9-acetamide | 957121-00-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 8-(3,5-Difluorophenyl)-8-methyl-10-oxo-N-(1a(2),3a(2),5,7-tetrahydro-2a(2)-oxospiro[6H-cyclopenta[b]pyridine-6,3a(2)-[3H]pyrrolo[2,3-b]pyridin]-3-yl)-6,9-diazaspiro[4.5]decane-9-acetamide
• 英文别名: 2-[8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-(2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-yl)acetamide
• CAS: 957121-00-5
• 化学式: C₃₁H₃₀F₂N₆O₃
• 分子量: 572.6
• InChiKey: IDKKNSOZWQOAAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  42
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Substituted monocyclic CGRP receptor antagonists
  申请人：Wood Michael R.

  公开号：US20070265225A1

  公开（公告）日：2007-11-15

  Compounds of formula I: (wherein variables A 1 , A 2 , A 3 , A 4 , m, n, J, Q, R 4 , E a , E b , E c , R 6 , R 7 , R e , R f , R PG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  式I的化合物：(其中变量A1、A2、A3、A4、m、n、J、Q、R4、Ea、Eb、Ec、R6、R7、Re、Rf、RPG和Y如本文所述)是CGRP受体拮抗剂，可用于治疗或预防涉及CGRP的疾病，如偏头痛。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及CGRP的疾病中使用这些化合物和组合物。
• [EN] SUBSTITUTED SPIROCYCLIC CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEURS CGRP MONOCYCLIQUES SUBSTITUÉS
  申请人：MERCK & CO INC

  公开号：WO2007133491A1

  公开（公告）日：2007-11-22

  [EN] Compounds of formula I: I (wherein variables A¹, A², A³, A⁴, M, N, J, Q, R⁴, E^a, E^b, E^c, R⁶, R⁷, R^e, R^f, R^PG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
  [FR] Composés de formula I: I (sachant que les variables A¹, A², A³, A⁴, M, N, J, Q, R⁴, E^a, E^b, E^c, R⁶, R⁷, R^e, R^f, R^PG et Y sont telles que spécifiées dans la description), qui sont des antagonistes de récepteurs CGRP, utiles dans le traitement ou la prévention de maladies dans lesquelles intervient le CGRP, du type migraine. Également, compositions pharmaceutiques renfermant ces composés et utilisation des composés et compositions en question dans la prévention ou le traitement des maladies considérées, dans lesquelles intervient le CGRP.