2-(4-chloro-benzenesulfonyl)-8-(4-methyl-piperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline | 807330-22-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-chloro-benzenesulfonyl)-8-(4-methyl-piperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline
• 英文别名: 2-(4-chlorophenyl)sulfonyl-8-(4-methylpiperazin-1-yl)-3,4-dihydro-1H-isoquinoline
• CAS: 807330-22-9
• 化学式: C₂₀H₂₄ClN₃O₂S
• 分子量: 405.948
• InChiKey: OCBMJRMULSRRDY-UHFFFAOYSA-N

物化性质

• 沸点：
  581.2±60.0 °C(Predicted)
• 密度：
  1.310±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  52.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Novel tetrahydroquinolines
  申请人：Pfizer Inc

  公开号：US20040254193A1

  公开（公告）日：2004-12-16

  The present invention relates to compounds of formula I 1 wherein X and Y are as defined in the specification, and to pharmaceutical compositions comprising the compound of formula I and a pharmaceutically effective carrier; and to a method useful in treating or preventing in mammals, including humans, a disorder or condition selected from the group consisting of anxiety, depression, dysthymia, major depressive disorder, migraine, post-traumatic stress disorder, avoidant personality disorder, borderline personality disorder and phobias.

  本发明涉及公式I1的化合物，其中X和Y如规范中定义的那样，以及包括公式I的化合物和药效载体的药物组合物；以及一种用于治疗或预防哺乳动物，包括人类，中的焦虑、抑郁、忧郁症、重度抑郁症、偏头痛、创伤后应激障碍、回避性人格障碍、边缘性人格障碍和恐惧症等疾病或症状的方法。
• NOVEL TETRAHYDROQUINOLINES
  申请人：Pfizer Products Inc.

  公开号：EP1641760A2

  公开（公告）日：2006-04-05
• US7101881B2
  申请人：——

  公开号：US7101881B2

  公开（公告）日：2006-09-05
• [EN] NOVEL TETRAHYDROQUINOLINES<br/>[FR] TETRAHYDROQUINOLEINES NOUVELLES
  申请人：PFIZER PROD INC

  公开号：WO2004108682A2

  公开（公告）日：2004-12-16

  The present invention relates to compounds of formula (I) wherein X and Y are as defined in the specification, and to pharmaceutical compositions comprising the compound of formula I and a pharmaceutically effective carrier; and to a method useful in treating or preventing in mammals, including humans, a disorder or condition selected from the group consisting of anxiety, depression, dysthymia, major depressive disorder, migraine, post-traumatic stress disorder, avoidant personality disorder, borderline personality disorder and phobias.