Ethyl 4,5,6,7,8,9-hexahydro-1H-4,8-epiminocycloocta[c]pyrazole-6-carboxylate | 1363382-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Ethyl 4,5,6,7,8,9-hexahydro-1H-4,8-epiminocycloocta[c]pyrazole-6-carboxylate
• 英文别名: ethyl 4,5,12-triazatricyclo[6.3.1.02,6]dodeca-2(6),3-diene-10-carboxylate
• CAS: 1363382-78-8
• 化学式: C₁₂H₁₇N₃O₂
• 分子量: 235.28
• InChiKey: NNSJOFCDXFOIKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  67
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase
  申请人：Bowers Simeon

  公开号：US20070049612A1

  公开（公告）日：2007-03-01

  The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R 1 and R 2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.

  本发明提供了式I的N-环磺酰胺化合物和盐：其中A如说明书所述，R1和R2结合形成[3.3.1]或[3.2.1]环系统，其中氮原子连接到两个桥头碳，[3.3.1]或[3.2.1]环系统可选择地与杂环芳基或杂环烷基环融合。式I化合物对于治疗或预防认知障碍，如阿尔茨海默病，具有有用性。本发明还包括包含式I化合物的制药组合物、治疗认知障碍的方法，如阿尔茨海默病，以及用于制备式I化合物的中间体。
• US7345056B2
  申请人：——

  公开号：US7345056B2

  公开（公告）日：2008-03-18