tert-butyl (3S,5R)-3-amino-5-fluoropiperidine-1-carboxylate | 2059917-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl (3S,5R)-3-amino-5-fluoropiperidine-1-carboxylate
• CAS: 2059917-34-7；1955555-01-7
• 化学式: C₁₀H₁₉FN₂O₂
• 分子量: 218.271
• InChiKey: QHVIBSNJHHGNCZ-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)pyrimidine-5-carboxylic acid 、 tert-butyl (3S,5R)-3-amino-5-fluoropiperidine-1-carboxylate 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (+/-)-cis-tert-butyl 3-(2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)pyrimidine-5-carboxamido)-5-fluoropiperidine-1-carboxylate
  参考文献：
  名称：

  Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life

  摘要：

  DOI：

  10.1021/acsmedchemlett.3c00330

文献信息

• HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
  申请人：Hoffmann-La Roche Inc.

  公开号：US20210395239A1

  公开（公告）日：2021-12-23

  The present invention relates to compounds of formula (I), wherein R 1 to R 3 , A and Q are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
• [EN] HETEROCYCLIC AMIDES AND METHODS OF USING THE SAME<br/>[FR] AMIDES HÉTÉROCYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：[en]RGENTA THERAPEUTICS, INC.

  公开号：WO2023092098A1

  公开（公告）日：2023-05-25

  The present disclosure relates to compounds of Formula (I), and subformulas thereof, and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds of the present disclosure may act as small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded genes, and methods of use of the compounds for modulating splicing and treating related diseases and conditions. The compounds disclosed herein may possess activity toward various genetic pathways and are accordingly useful in methods of treatment of diseases or disorders of the human or animal body.