1-(2,4-Dimethylphenyl)-4-piperidin-1-ylsulfonylpiperazine | 692762-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2,4-Dimethylphenyl)-4-piperidin-1-ylsulfonylpiperazine
• CAS: 692762-00-8
• 化学式: C₁₇H₂₇N₃O₂S
• 分子量: 337.5
• InChiKey: WPBRWZIGDANJAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  512.2±50.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)
• 溶解度：
  3.8 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  52.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Compositions and methods for treating Helicobacter pylori infection
  申请人：The Hospital for Sick Children

  公开号：US11191760B2

  公开（公告）日：2021-12-07

  A method for treating and/or preventing VacA+ H. pylori infection and a disorder associated with VacA+ H. pylori infection is provided. The method comprises the administration of TRPML agonists such as ML-SA1, SF-22, SF-51, MK6-83 and their derivatives.

  提供了一种治疗和/或预防VacA+幽门螺杆菌感染和与VacA+幽门螺杆菌感染相关的疾病的方法。该方法包括服用 TRPML 激动剂，如 ML-SA1、SF-22、SF-51、MK6-83 及其衍生物。
• [EN] COMPOSITIONS AND METHODS FOR TREATING HELICOBACTER PYLORI INFECTION<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'UNE INFECTION À HELICOBACTER PYLORI
  申请人：HOSPITAL FOR SICK CHILDREN

  公开号：WO2017173544A1

  公开（公告）日：2017-10-12

  A method for treating and/or preventing VacA+ H. pylori infection and a disorder associated with VacA+ H. pylori infection is provided. The method comprises the administration of TRPML agonists such as ML-SA1, SF-22, SF-51, MK6-83 and their derivatives.