(5R)-5-[(4-fluoro-5-methoxy-3-oxo-1H-isoindol-2-yl)methyl]-5-[2-[6-[(4-pyridin-4-ylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl]imidazolidine-2,4-dione | 1226987-54-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (5R)-5-[(4-fluoro-5-methoxy-3-oxo-1H-isoindol-2-yl)methyl]-5-[2-[6-[(4-pyridin-4-ylpiperazin-1-yl)methyl]pyridin-3-yl]ethynyl]imidazolidine-2,4-dione
• CAS: 1226987-54-7
• 化学式: C₃₀H₂₈FN₇O₄
• 分子量: 569.595
• InChiKey: OLTZXHFVBSAVFE-SSEXGKCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
  申请人：Kozlowski Joseph A.

  公开号：US20120010181A1

  公开（公告）日：2012-01-12

  This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
• US8541572B2
  申请人：——

  公开号：US8541572B2

  公开（公告）日：2013-09-24