7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-1-dodecanoyl-3,4-dihydroquinolin-2(1H)-one | 1352726-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-1-dodecanoyl-3,4-dihydroquinolin-2(1H)-one
• 英文别名: 7-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy]-1-dodecanoyl-3,4-dihydroquinolin-2-one
• CAS: 1352726-42-1
• 化学式: C₃₅H₄₉Cl₂N₃O₃
• 分子量: 630.698
• InChiKey: PCCOXCZAJHDKFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  43
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  53.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES
  申请人：Blumberg Laura Cook

  公开号：US20110319422A1

  公开（公告）日：2011-12-29

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  该发明提供了一种持续释放内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药的方法，通过向患者施用该发明的一种前药化合物的有效量，在向患者施用后，从前药中释放母药是持续释放的。适用于该发明方法的前药化合物是母药的不稳定结合物，通过羰基连接的前药基团进行衍生化。该发明的前药化合物可用于治疗任何需要内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药作为治疗的情况。
• [EN] IMPROVED PROCESS FOR THE PREPARATION OF 7-{4-[4-(2,3-DICHLOROPHENYL)-PIPERAZIN-1-YL]BUTOXY}-2OXO-3,4-DIHYDRO-2H-QUINOLIN-1-YL)METHYL DODECANOATE<br/>[FR] PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE 7-{4-[4-(2,3-DICHLOROPHÉNYL)-PIPÉRAZIN-1-YL]BUTOXY}-2OXO-3,4-DIHYDRO-2H-QUINOLIN-1-YL)MÉTHYL DODÉCANOATE
  申请人：MSN LABORATORIES PRIVATE LTD R&D CENTER

  公开号：WO2018104953A1

  公开（公告）日：2018-06-14

  The present invention relates to improved process for the preparation of 7-4-[4- (2,3-dichlorophenyl)-piperazin-1-yl]butoxy }-2 oxo-3,4-dihydro-2H-quinolin-1-yl)methyl dodecanoate compound of formula-1, which is represented by the following structural formula:

  本发明涉及改进的制备方法，用于制备化合物7-4-[4-(2,3-二氯苯基)-哌嗪-1-基]氧基}-2-氧代-3,4-二氢-2H-喹啉-1-基)甲基十二烷酸酯的配方-1，其由以下结构式表示：
• Prodrugs of NH-Acidic Compounds: Ester, Carbonate, Carbamate and Phosphonate Derivatives
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20170196848A1

  公开（公告）日：2017-07-13

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
• US8592427B2
  申请人：——

  公开号：US8592427B2

  公开（公告）日：2013-11-26
• US9072788B2
  申请人：——

  公开号：US9072788B2

  公开（公告）日：2015-07-07