2-amino-N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-benzamide hydrochloride | 1108743-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-amino-N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-benzamide hydrochloride
• 英文别名: N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-2-amino-4-(4-methylpiperazin-1-yl)benzamide hydrochloride；2-amino-N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide;hydrochloride
• CAS: 1108743-93-6
• 化学式: C₂₆H₂₆F₂N₆O*ClH
• 分子量: 512.99
• InChiKey: KFRVKWIHJGIQNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.44
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  90.3
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'INDAZOLE SUBSTITUÉS ACTIFS COMME INHIBITEURS DE KINASES
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2009013126A1

  公开（公告）日：2009-01-29

  Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.

  公开了公式（I）的吲唑衍生物及其药用盐，如规范中定义的，以及它们的制备方法和包含它们的药物组合物；本发明的化合物可能在治疗与蛋白激酶活性失调相关的疾病，如癌症方面有用。
• SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
  申请人：LOMBARDI BORGIA Andrea

  公开号：US20130018036A1

  公开（公告）日：2013-01-17

  Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.

  本发明披露了式（I）的取代吲唑衍生物及其药学上可接受的盐，其定义在说明书中，以及其制备过程和包含它们的制药组合物；本发明的化合物可能在治疗与蛋白激酶活性失调相关的疾病，如癌症中有用。
• Substituted indazole derivatives active as kinase inhibitors
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：US10081622B2

  公开（公告）日：2018-09-25

  Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.

  如说明书中所定义的式(I)的取代吲唑衍生物及其药学上可接受的盐；本发明的化合物可用于治疗与蛋白激酶活性失调有关的疾病，如癌症。
• US8299057B2
  申请人：——

  公开号：US8299057B2

  公开（公告）日：2012-10-30
• US8673893B2
  申请人：——

  公开号：US8673893B2

  公开（公告）日：2014-03-18