4-(3-chloropyridin-2-yl)-N-(6-ethoxy-1,3-benzothiazol-2-yl)piperazine-1-carboxamide | 722497-51-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(3-chloropyridin-2-yl)-N-(6-ethoxy-1,3-benzothiazol-2-yl)piperazine-1-carboxamide
• CAS: 722497-51-0
• 化学式: C₁₉H₂₀ClN₅O₂S
• 分子量: 417.919
• InChiKey: GALKAXWPHCXKJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  98.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
  申请人：Purdue Pharma L.P.

  公开号：US20140142112A1

  公开（公告）日：2014-05-22

  A compound of formula: wherein Ar 1 , A, R 3 , X, and m are as disclosed herein and Ar 2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.
• US8536177B2
  申请人：——

  公开号：US8536177B2

  公开（公告）日：2013-09-17
• US9434721B2
  申请人：——

  公开号：US9434721B2

  公开（公告）日：2016-09-06