(S)-tert-butyl 4-(5-hydroxypyrimidin-2-yl)-2-methylpiperazine-1-carboxylate | 1272973-59-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (S)-tert-butyl 4-(5-hydroxypyrimidin-2-yl)-2-methylpiperazine-1-carboxylate
• 英文别名: tert-butyl (2S)-4-(5-hydroxypyrimidin-2-yl)-2-methylpiperazine-1-carboxylate
• CAS: 1272973-59-7
• 化学式: C₁₄H₂₂N₄O₃
• 分子量: 294.354
• InChiKey: PNCVXHCLFZWNEH-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  78.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Therapeutic Agents 812
  申请人：Birch Alan Martin

  公开号：US20110065706A1

  公开（公告）日：2011-03-17

  A compound of formula I or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as GPR119 modulators, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus, and pharmaceutical compositions containing them.

  公式I的化合物或其药用可接受的盐，制备这类化合物的方法，它们作为GPR119调节剂的用途，它们的治疗用途的方法，特别是在肥胖和糖尿病的治疗中，以及含有它们的药物组合物。
• FURIN INHIBITORS
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：EP3790871A1

  公开（公告）日：2021-03-17
• [EN] FURIN INHIBITORS<br/>[FR] INHIBITEURS DE FURINE
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2019215341A1

  公开（公告）日：2019-11-14

  This invention relates to novel compounds according to Formula (I) which are inhibitors of furin, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of fibrotic diseases, including pulmonary fibrosis, renal fibrosis, liver fibrosis, skin fibrosis, ocular fibrosis, cardiac fibrosis, and other miscellaneous fibrotic conditions. The disclosed compounds may also be useful for treating other furin-mediated conditions, including but not limited to, hypertension, cancer, infectious diseases, and genetic disorders (e.g., cystic fibrosis (CF)), and neurodegenerative disorders.