| 1192767-68-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• CAS: 1192767-68-2
• 化学式: C₃₇H₅₄O₁₂
• 分子量: 690.829
• InChiKey: IGPWYKNSJVLRFJ-YEVAHTQGSA-N

反应信息

• 作为产物：
  描述：

  2-羟基-4-[2-羟基-6-十五烷基-4-[(2S,3R,4S,5R,6R)-3,4,5-三羟基-6-(羟基甲基)四氢吡喃-2-基]氧基苯甲酰基]氧基-6-甲基苯甲酸 、 三甲基硅烷化重氮甲烷 以 甲醇 、 正己烷 为溶剂， 反应 2.0h， 以0.5 mg的产率得到
  参考文献：
  名称：

  Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060

  摘要：

  In the course of bioassay-guided study on the EtOAc extract of a culture broth of the marine-derived fungus Cosmospora sp. SF-5060, aquastatin A (1) was isolated as a protein tyrosine phosphatase 1B (PTP1B) inhibitory component produced by the fungus. The compound was isolated by various chromatographic methods, and the structure was determined mainly by analysis of NMR spectroscopic data. Compound 1 exhibited potent inhibitory activity against PTP1B with IC50 value of 0.19 mu M, and the kinetic analyses of PTP1B inhibition by compound 1 suggested that the compound is inhibiting PTP1B activity in a competitive manner. Aquastatin A (1) also showed modest but selective inhibitory activity toward PTP1B over other protein tyrosine phosphatases, such as TCPTP, SHP-2, LAR, and CD45. In addition, the result of hydrolyzing aquastatin A (1) suggested that the dihydroxypentadecyl benzoic acid moiety in the molecule is responsible for the inhibitory activity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.09.025