2-[4-(1-Methylethyl)-1-piperazinyl]-6-quinolinecarbonitrile | 577967-90-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(1-Methylethyl)-1-piperazinyl]-6-quinolinecarbonitrile
• 英文别名: 2-(4-propan-2-ylpiperazin-1-yl)quinoline-6-carbonitrile
• CAS: 577967-90-9
• 化学式: C₁₇H₂₀N₄
• 分子量: 280.37
• InChiKey: GZBQWMWZEZTKSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Novel aryl- and heteroarylpiperazines
  申请人：——

  公开号：US20030236259A1

  公开（公告）日：2003-12-25

  Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.

  新颖的芳基和杂环基哌嗪类化合物，这些化合物作为药物组合物的用途，包含这些化合物的药物组合物，以及利用这些化合物和组合物的治疗方法。这些化合物显示出对组胺H3受体的高度和选择性结合亲和力，表明具有组胺H3受体拮抗、逆激动或激动活性。因此，这些化合物对于治疗与组胺H3受体相关的疾病和紊乱是有用的。
• Novel Aryl- and Heteroarylpiperazines
  申请人：Hohlweg Rolf

  公开号：US20090264435A1

  公开（公告）日：2009-10-22

  Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.

  新型芳基和杂环基哌嗪，这些化合物的药用组合物，包含这些化合物的药用组合物，以及采用这些化合物和组合物的治疗方法。这些化合物表现出高度和选择性的结合亲和力，表明它们具有组胺H3受体拮抗、反向激动或激动活性。因此，这些化合物对于治疗与组胺H3受体相关的疾病和障碍非常有用。
• NOVEL ARYL- AND HETEROARYLPIPERAZINES
  申请人：NOVO NORDISK A/S

  公开号：EP1474401A2

  公开（公告）日：2004-11-10
• [EN] NOVEL ARYL- AND HETEROARYLPIPERAZINES<br/>[FR] NOUVELLES ARYL- ET HETEROARYLPIPERAZINES
  申请人：NOVO NORDISK AS

  公开号：WO2003066604A2

  公开（公告）日：2003-08-14

  Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.